TY - JOUR
AU - Struhl, Kevin
AB - Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function.
TI - Transcriptional noise and the fidelity of initiation by RNA polymerase II
JF - Nature Structural & Molecular Biology
DO - 10.1038/nsmb0207-103
DA - 2007-02-01
UR - https://www.deepdyve.com/lp/springer-journals/transcriptional-noise-and-the-fidelity-of-initiation-by-rna-polymerase-ohBTh00Efk
SP - 103
EP - 105
VL - 14
IS - 2
DP - DeepDyve
ER -