TY - JOUR
AU - Saksida, Lisa M
AB - CORRESPONDENCE Measuring cognitive deficits in disabled Mice learned to discriminate between the stimuli within 10 d (Fig. 1c,d). On day 11 we reversed the task, so the previously cor- mice using an automated interactive rect stimulus was now incorrect. On the first day of reversal, all touchscreen system mice showed a significant (P < 0.001) decrease in correct choices, as they continued to choose the previously correct stimulus. After To the editor: The concomitant appearance of motor disability that, wild-type and R6/2 mice in the younger cohort began to and cognitive deficits is very common in neurodegenerative dis- learn the reversal, and by day 22 they had learned the task (Fig. ease . Although progress in developing valuable mouse models 1c). Older R6/2 mice, however, showed significant impairments for these diseases has been excellent, there are few cognitive tests in reversal learning (P < 0.05; Fig. 1d). suitable for animals with motor impairments. To tackle this prob- At the end of reversal testing, we presented mice in the younger lem, we used an automated touchscreen-based cognitive-testing cohort with a new pair of stimuli (Fig. 1c). In contrast to wild- system that can be used to test mice with motor 
TI - Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system
JO - Nature Methods
DO - 10.1038/nmeth1006-767
DA - 2006-10-01
UR - https://www.deepdyve.com/lp/springer-journals/measuring-cognitive-deficits-in-disabled-mice-using-an-automated-pRK9YVq0D8
SP - 767
EP - 767
VL - 3
IS - 10
DP - DeepDyve
ER -