TY - JOUR
AU - Lesage, Florian
AB - TWIK1 belongs to a family of K+ channels involved in neuronal excitability and cell volume regulation. Its tissue distribution suggests a role in epithelial potassium transport. Here we show that TWIK1 is expressed in a subapical compartment in renal proximal tubules and in polarized MDCK cells. In nonpolarized cells, this compartment corresponds to pericentriolar recycling endosomes. We identified EFA6, an exchange factor for the small G protein ADP‐ribosylation factor 6 (ARF6), as a protein binding to TWIK1. EFA6 interacts with TWIK1 only when it is bound to ARF6. Because ARF6 modulates endocytosis at the apical surface of epithelial cells, the ARF6/EFA6/TWIK1 association is probably important for channel internalization and recycling.
TI - ARF6‐dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6
JF - EMBO Reports
DO - 10.1038/sj.embor.7400292
DA - 2004-12-01
UR - https://www.deepdyve.com/lp/springer-journals/arf6-dependent-interaction-of-the-twik1-k-channel-with-efa6-a-gdp-gtp-pcbFSRNo00
SP - 1171
EP - 1175
VL - 5
IS - 12
DP - DeepDyve
ER -