TY - JOUR
AU1 - Evans, D. Gareth
AB -  In the current issue of the journal, two further studies confirm a likely increased risk of breast cancer amongst NF1 females who are <50 years of age [Madanikia et al., 2012 ; Wang et al., 2012 ]. Wang et al. [ 2012 ] found nine breast cancers among 76 NF1 affected women consistent with an increase of breast cancer incidence (SIR = 5.2; 95% CI: 2.4–9.8), and with this increase especially evident among those with breast cancer onset <50 years of age (SIR = 8.8; 95% CI: 3.2–19.2). Madanikia et al. [ 2012 ] found four breast cancer cases among 126 NF1 affected women consistent with a relative risk (adjusted for race, the prevalence of NF1 in the general population, and time of diagnosis) of 4.41 ( P = 0.0049, CI: 1.12–12.00). While both of these studies are small, the data are supportive of previous research in the United Kingdom also confirming a four to fivefold increased relative risk of breast cancer in NF1 females aged <50 years [Walker et al., 2006 ; Sharif et al., 2007 ]. Whereas earlier epidemiological studies failed to detect an increased risk of breast cancer [Sørensen et al., 1986 ; Rasmussen et 
TI - Are we ready for targeted early breast cancer detection strategies in women with NF1 aged 30–49 years?
JF - American Journal of Medical Genetics Part A
DO - 10.1002/ajmg.a.35585
DA - 2012-12-01
UR - https://www.deepdyve.com/lp/wiley/are-we-ready-for-targeted-early-breast-cancer-detection-strategies-in-q24W1gg4Sj
SP - 3054
EP - 3055
VL - 158A
IS - 12
DP - DeepDyve
ER -