TY - JOUR
AU1 - Yin, Baoqi
AU2 - Li, Honglei
AU3 - Zhao, Pengju
AU4 - Zhao, Yonghong
AU5 - Zheng, Ruijuan
AU6 - Feng, Pengya
AU7 - Xu, Cuixiang
AU8 - Li, Enyao
AU9 - Li, Liguo
AB - Autism spectrum disorder (ASD) is a neurodevelopmental disorder that cannot be cured. The ASD rat model was developed in this study to demonstrate the role and mechanism of ganglioside GM1 (GM1). Rats were given valproic acid (VPA) to create the ASD rat model. The rats’ behaviors were assessed using the Y-maze test, open-field test, three-chamber social interaction test, and Morris water maze test. Relative levels of glutathione (GSH), malondialdehyde (MDA), catalase (CAT), reactive oxygen species (ROS), and superoxide dismutase (SOD) were quantitated using relative kits. Nissl, TUNEL, immunofluorescent, and immunohistochemistry staining techniques were used. GM1 treatment improved the ASD model rats’ behavior disorders, including locomotor activity and exploratory behavior, social interaction, learning and memory capacity, and repetitive behavior. Following GM1 injection, striatal neurons grew and apoptosis decreased. GM1 reduced the excessively elevated α-Syn in ASD by encouraging autophagy. The behavior disorder of ASD model rats was exacerbated by autophagy inhibition, which also increased α-Syn levels. By increasing autophagy, GM1 reduced α-Syn levels and, ultimately, improved behavioral abnormalities in ASD model rats.
TI - GM1 Reduced the Symptoms of Autism Spectrum Disorder by Suppressing α-Syn Through Activating Autophagy
JF - Journal of Molecular Neuroscience
DO - 10.1007/s12031-023-02110-5
DA - 2023-05-01
UR - https://www.deepdyve.com/lp/springer-journals/gm1-reduced-the-symptoms-of-autism-spectrum-disorder-by-suppressing-qjqM8AipWu
SP - 287
EP - 296
VL - 73
IS - 4-5
DP - DeepDyve
ER -