TY - JOUR
AU1 - Movat, Henry Z.
AB - History of Pathology © 1989 S. Karger AG, Basel Pathol Im munopathol Res 1989;8:35-41 0257-2761/89/0081-0035S2.7S/0 The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries Henry Z. Movat Departments of Pathology and of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ont., Canada There are 3 or 4 events in leukocyte emi­ presumably emigration, by rendering endo­ gration: (a) vasomotor changes; (b) adhesion thelial cells hyperadhesive for leukocytes. of the leukocytes to the endothelial lining of Thus two mechanisms of leukocyte emigra­ postcapillary and larger venules; (c) emigra­ tion have been proposed: one leukocyte-de­ tion through the vessel wall, and (d) migra­ pendent (induced by chemotaxins and not tion to the inflammatory focus, presumably dependent on protein synthesis) and another along a chemotactic gradient. How deep into endothelial-dependent (induced by endo­ the vessel chemotaxins reach from the site of toxin or interleukin 1 and protein synthesis- their generation in the tissue is uncertain. dependent) [reviewed by Bevilacqua et al., Some investigators believe, based on in vitro 1987b; Harlan et al., 1987]. In vivo observa­ observations, that in vivo as well chemotax­ tions partially support this concept [Me ins may reach the leukocytes in the 
TI - The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries
JF - Pathology and Immunopathology Research
DO - 10.1159/000157136
DA - 1989-01-01
UR - https://www.deepdyve.com/lp/karger/the-role-of-endothelium-in-leukocytes-emigration-the-views-of-cohnheim-rkQqzVWiMe
SP - 35
EP - 41
VL - 8
IS - 1
DP - DeepDyve
ER -