TY - JOUR
AU - Beaulieu, J-M
AB - Glycogen synthase kinase 3 (GSK3), a prominent enzyme in carbohydrate metabolism, also has a major role in brain function. It is physiologically regulated by the kinase Akt, which phosphorylates GSK3 to inhibit catalytic activity. Inositol hexakisphosphate-1 (IP6K1) generates the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7), which physiologically inhibits Akt leading to enhanced GSK3 activity. We report that IP6K1 binds and stimulates GSK3 enzymatic activity in a non-catalytic fashion. Physiological relevance is evident in the inhibition of GSK3 activity in the brains of IP6K1-deleted mice. Behavioral alterations of IP6K1 knockout mice resemble those of GSK3 mutants. Accordingly, modulation of IP6K1–GSK3β interaction may exert beneficial effects in psychiatric disorders involving GSK3.
TI - Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways
JF - Molecular Psychiatry
DO - 10.1038/mp.2013.21
DA - 2013-02-26
UR - https://www.deepdyve.com/lp/springer-journals/inositol-hexakisphosphate-kinase-1-regulates-behavioral-responses-via-tB8NI6Vd9J
SP - 284
EP - 293
VL - 19
IS - 3
DP - DeepDyve
ER -