TY - JOUR
AU - Kuo, M., Tien
AB - Abstract P-glycoprotein has been show to be responsible for multidrug resistance in mammalian cells. However, its Physiological roles in normal cells are not known. The gene encoding this protein has been shown to express at a relatively high level in human digestive tracts. In the present study, in situ hybridizations were employed to determine the expression of this gene in gastrointestinal tissues. Epithelial cells in this villi of small intestine, colon, and stomach were rich in the P-glycoprotein gene transcript, Observation were Consistent with the idea that the P-glycoprotein plays a role in detoxification by pumping potentially harmful compounds into the lumen of digestive tracts in animals. [J Natal Cancer Inst 1988;80:269–275] This content is only available as a PDF. Author notes 2Supported in part by public Health Service grants CA-43621 from the National Cancer Institute and GM-28573 from the National Institute of General Medical Sciences, National Institutes of Health, Department of Health and Human Services; and by the Robert A. Welch Foundation (G831). 4We are indebted to Dr. T. C. Hsu, Department of Genetics, M. D. Anderson Hosptial, for providing Chinese hamsters, and to Miss Betty Mckinney for frozen sectioning of tissues. We especially thank Dr. Michael Gottesman for the exchange of experimental results. © Oxford University Press
TI - Expression of the mdr (P-glycoprotein) Gene in Chinese Hamster Digestive Tracts1
JF - JNCI: Journal of the National Cancer Institute
DO - 10.1093/jnci/80.4.269
DA - 1988-04-20
UR - https://www.deepdyve.com/lp/oxford-university-press/expression-of-the-mdr-p-glycoprotein-gene-in-chinese-hamster-digestive-tM01NgQ0gR
SP - 269
EP - 275
VL - 80
IS - 4
DP - DeepDyve
ER -