TY - JOUR AU - Steptoe, Andrew AB - Positive Psychological Well-Being and Mortality: A Quantitative Review of Prospective Observational Studies YOICHI CHIDA, MD, PHD, AND ANDREW STEPTOE,DPHIL Objective: To review systematically prospective, observational, cohort studies of the association between positive well-being and mortality using meta-analytic methods. Recent years have witnessed increased interest in the relationship between positive psychological well-being and physical health. Methods: We searched general bibliographic databases: Medline, PsycINFO, Web of Science, and PubMed up to January 2008. Two reviewers independently extracted data on study characteristics, quality, and estimates of associations. Results: There were 35 studies (26 articles) investigating mortality in initially healthy populations and 35 studies (28 articles) of disease populations. The meta-analyses showed that positive psychological well-being was associated with reduced mortality in both the healthy population (combined hazard ratio (HR)  0.82; 95% Confidence Interval (CI) 0.76–0.89; p  .001) and the disease population (combined HR  0.98; CI  0.95–1.00; p  .030) studies. There were indications of publication bias in this literature, although the fail-safe numbers were 2444 and 1397 for healthy and disease population studies, respectively. Intriguingly, meta-analysis of studies that controlled for negative affect showed that the protective effects of positive psychological well-being were independent of negative affect. Both TI - Positive Psychological Well-Being and Mortality: A Quantitative Review of Prospective Observational Studies JF - Psychosomatic Medicine DO - 10.1097/PSY.0b013e31818105ba DA - 2008-09-01 UR - https://www.deepdyve.com/lp/wolters-kluwer-health/positive-psychological-well-being-and-mortality-colon-a-quantitative-tXJub82H3A SP - 741 EP - 756 VL - 70 IS - 7 DP - DeepDyve ER -