TY - JOUR AU - Lu, Zhimin AB -

Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling, phosphorylates β-catenin at Ser552 in vitro and in vivo. AKT-mediated phosphorylation of β-catenin causes its disassociation from cell-cell contacts and accumulation in both the cytosol and the nucleus and enhances its interaction with 14-3-3ζ via a binding motif containing Ser552. Phosphorylation of β-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of β-catenin plays a critical role in tumor invasion and development.

TI - Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity * JF - Journal of Biological Chemistry DO - 10.1074/jbc.m611871200 DA - 2007-04-13 UR - https://www.deepdyve.com/lp/american-society-for-biochemistry-and-molecular-biology/phosphorylation-of-catenin-by-akt-promotes-catenin-transcriptional-taeWWOfV8T SP - 11221 EP - 11229 VL - 282 IS - 15 DP - DeepDyve ER -