TY - JOUR AU1 - Nissen, Peter AU2 - Brassard, Patrice AU3 - Jørgensen, Thomas AU4 - Secher, Niels AB - Neurocrit Care (2010) 12:17–23 DOI 10.1007/s12028-009-9313-x ORIG IN AL ARTI CLE Phenylephrine but not Ephedrine Reduces Frontal Lobe Oxygenation Following Anesthesia-Induced Hypotension • • • Peter Nissen Patrice Brassard Thomas B. Jørgensen Niels H. Secher Published online: 3 December 2009 Springer Science+Business Media, LLC 2009 Abstract Abbreviations Background Vasopressor agents are used to correct anes- CBF Cerebral blood flow thesia-induced hypotension. We describe the effect of CO Cardiac output phenylephrine and ephedrine on frontal lobe oxygenation HR Heart rate (S O ) following anesthesia-induced hypotension. MAP Mean arterial pressure c 2 Methods Following induction of anesthesia by fentanyl NIRS Near infrared spectroscopy -1 -1 (0.15 mg kg ) and propofol (2.0 mg kg ), 13 patients S O Frontal lobe cerebral oxygenation c 2 received phenylephrine (0.1 mg iv) and 12 patients received SV Stroke volume ephedrine (10 mg iv) to restore mean arterial pressure (MAP). Heart rate (HR), MAP, stroke volume (SV), cardiac Introduction output (CO), and frontal lobe oxygenation (S O ) were c 2 registered. Results Induction of anesthesia was followed by a decrease Induction of anesthesia may lead to a decrement in arterial pressure that could be considered below the lower limit of in MAP, TI - Phenylephrine but not Ephedrine Reduces Frontal Lobe Oxygenation Following Anesthesia-Induced Hypotension JF - Neurocritical Care DO - 10.1007/s12028-009-9313-x DA - 2009-12-03 UR - https://www.deepdyve.com/lp/springer-journals/phenylephrine-but-not-ephedrine-reduces-frontal-lobe-oxygenation-uczSbOlr0y SP - 17 EP - 23 VL - 12 IS - 1 DP - DeepDyve ER -