TY - JOUR
AU - Devlin, James J.
AB - Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction Dov Shiffman, Charles M. Rowland, Judy Z. Louie, May M. Luke, Lance A. Bare, Joel I. Bolonick, Bradford A. Young, Joseph J. Catanese, Charles F. Stiggins, Clive R. Pullinger, Eric J. Topol, Mary J. Malloy, John P. Kane, Stephen G. Ellis, James J. Devlin Objectives—Identify gene variants associated with early-onset myocardial infarction (MI). Methods and Results—We tested 11 647 single-nucleotide polymorphisms (SNPs) for association with early-onset MI in a case-control study (study 1 200 cases, 262 controls). To reduce the number of false positives among the 666 SNPs that were nominally associated with early-onset MI (P
0.05) in study 1, we tested these SNPs in study 2 (434 cases, 504 controls). We found that 8 of the 666 SNPs were associated with early-onset MI in study 2 (P
0.05) and had the same risk alleles as in study 1. These 8 SNPs were then tested for association with early-onset MI in study 3 (187 cases, 434 controls). We found that a VAMP8 variant (P0.025; odds ratio [OR], 1.75; CI, 1.17 to 2.62) and an HNRPUL1 variant (P0.0043; OR, 1.92; CI, 1.28 to 2.86) were associated with early-onset MI (nominal 
TI - Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
DO - 10.1161/01.ATV.0000226543.77214.e4
DA - 2006-07-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/gene-variants-of-vamp8-and-hnrpul1-are-associated-with-early-onset-uu1aCELSez
SP - 1613
EP - 1618
VL - 26
IS - 7
DP - DeepDyve
ER -