TY - JOUR
AU - Bulavin, Dmitry V.
AB - The ataxia telangiectasia mutated (ATM) kinase is a key tumor suppressor that regulates numerous cell cycle checkpoints as well as apoptosis. Here, we report that ATM is a critical player in the regulation of apoptosis and lymphomagenesis in the presence of c-myc. In turn, deletion of the inhibitory ATM phosphatase, Wip1, results in ATM up-regulation and suppression of Eμ-myc–induced B cell lymphomas. Using mouse genetic crosses, we show that the onset of myc-induced lymphomas is dramatically delayed in Wip1-null mice in an ATM- and p53-, but not p38 MAPK– or Arf-, dependent manner. We propose that Wip1 phosphatase is critical for regulating the ATM-mediated tumor surveillance network.
TI - Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
JF - The Journal of Experimental Medicine
DO - 10.1084/jem.20061563
DA - 2006-12-25
UR - https://www.deepdyve.com/lp/pubmed-central/regulation-of-atm-p53-dependent-suppression-of-myc-induced-lymphomas-vF15Vh4vG5
SP - 2793
EP - 2799
VL - 203
IS - 13
DP - DeepDyve
ER -