TY - JOUR
AU1 - Oytun, Merve Güner
AU2 - Ceylan, Serdar
AU3 - Koca, Meltem
AU4 - Öztürk, Yelda
AU5 - Baş, Arzu Okyar
AU6 - Balcı, Cafer
AU7 - Doğu, Burcu Balam
AU8 - Halil, Meltem Gülhan
AU9 - Cankurtaran, Mustafa
AB - PurposeSodium-glucose transporter-2  (SGLT-2) inhibitors are second-line therapy in type 2 diabetes mellitus (DM) with or without metformin based on glycemic needs. However, the safety and efficacy of SGLT-2 inhibitors in older adults are controversial, and not sufficient evidence is present in the use of older adults with DM.MethodsForty-one patients with DM, who were started on a new SGLT-2 inhibitor between 2019 and 2021, were included in the study. Patients’ records were reviewed retrospectively. Demographic features, components of comprehensive geriatric assessment, laboratory values including glycosylated hemoglobin (HbA1c), renal functions, and urinary analysis were recorded. Complications regarding dehydration, genitourinary infections, acute renal failure, and emergency department admission with euglycemic ketoacidosis or serious infection related to SGLT-2 inhibitors were also documented.ResultsThe mean age of participants was 69 ± 5.3 years, and 20 patients were living with frailty via the clinical frailty scale. The median follow-up time was 5.0 (3.0–7.0) months. The mean ± SD HbA1c before SGLT-2 inhibitors was 8.56 ± 2.12%, and after treatment, it was 8.13 ± 1.25% in patients living with frailty (p > 0.05). HbA1c level before SGLT-2 inhibitor treatment was observed as 8.87 ± 2.08%, and it was 7.44 ± 0.87% after the treatment among non-frail patients (p < 0.05). Complication rates related to SGLT-2 inhibitors were significantly higher in the patients living with frailty than in the non-frail patients (40% vs 9.5%, respectively p < 0.05).ConclusionPatients living with frailty are more vulnerable to adverse effects of SGLT-2 inhibitors, and their benefits are limited. Therefore, it should be used with caution in older adults with frailty. Longitudinal prospective studies should be conducted to support our findings.
TI - Benefits vs risks: SGLT-2 inhibitors in older adults living with frailty: a retrospective study from a university hospital
JF - International Journal of Diabetes in Developing Countries
DO - 10.1007/s13410-023-01175-7
DA - 2023-10-01
UR - https://www.deepdyve.com/lp/springer-journals/benefits-vs-risks-sglt-2-inhibitors-in-older-adults-living-with-vQLgidCRS3
SP - 758
EP - 764
VL - 43
IS - 5
DP - DeepDyve
ER -