TY - JOUR
AU - Rao, Shao-Qi
AB - Genetic studies are traditionally based on single-gene analysis. The use of these analyses can pose tremendous challenges for elucidating complicated genetic interplays involved in complex human diseases. Modern pathway-based analysis provides a technique, which allows a comprehensive understanding of the molecular mechanisms underlying complex diseases. Extensive studies utilizing the methods and applications for pathway-based analysis have significantly advanced our capacity to explore large-scale omics data, which has rapidly accumulated in biomedical fields. This article is a comprehensive review of the pathway-based analysis methods—the powerful methods with the potential to uncover the biological depths of the complex diseases. The general concepts and procedures for the pathway-based analysis methods are introduced and then, a comprehensive review of the major approaches for this analysis is presented. In addition, a list of available pathway-based analysis software and databases is provided. Finally, future directions and challenges for the methodological development and applications of pathway-based analysis techniques are discussed. This review will provide a useful guide to dissect complex diseases.
TI - Pathway-Based Analysis Tools for Complex Diseases: A Review
JF - Genomics Proteomics & Bioinformatics
DO - 10.1016/j.gpb.2014.10.002
DA - 2014-10-28
UR - https://www.deepdyve.com/lp/oxford-university-press/pathway-based-analysis-tools-for-complex-diseases-a-review-ykpEzjT2rE
SP - 210
EP - 220
VL - 12
IS - 5
DP - DeepDyve
ER -