TY - JOUR AU - , AB - In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies. TI - QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. JF - Annals of Internal Medicine DO - 10.7326/0003-4819-155-8-201110180-00009 DA - 2011-12-19 UR - https://www.deepdyve.com/lp/pubmed/quadas-2-a-revised-tool-for-the-quality-assessment-of-diagnostic-yxUu26iZ1d SP - 529 EP - 3652936 VL - 155 IS - 8 DP - DeepDyve ER -