TY - JOUR
AU - Pagano, Joseph S
AB - Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.
TI - Structure and function of IRF-7.
JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
DO - 10.1089/107999002753452700
DA - 2002-06-17
UR - https://www.deepdyve.com/lp/pubmed/structure-and-function-of-irf-7-zVziS6MJO0
SP - 95
EP - 101
VL - 22
IS - 1
DP - DeepDyve
ER -