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Pediatr Radiol (2017) 47:1345–1352 DOI 10.1007/s00247-017-3874-1 ORIGINAL ARTICLE Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children 1 1 1,2 Maria Camilla Rossi Espagnet & Bruno Bernardi & Luca Pasquini & 1 3 4 Lorenzo Figà-Talamanca & Paolo Tomà & Antonio Napolitano Received: 28 December 2016 /Revised: 26 March 2017 /Accepted: 20 April 2017 /Published online: 19 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract between administrations, age, radiotherapy and chemotherapy. Background Few studies have been conducted on the rela- T-test analyses were performed to compare signal intensity ratio tions between T1-weighted signal intensity changes in the differences between successive administrations and baseline pediatric brain following gadolinium-based contrast agent MR signal intensity ratios in patients compared to controls. P- (GBCA) exposure. values were considered significant if <0.05. Objective The purpose of this study is to investigate the effect Results A significant effect of the number of GBCA adminis- of multiple administrations of a macrocyclic GBCA on signal trations on relative signal intensities globus pallidus-to-thalamus intensity in the globus pallidus and dentate nucleus of the (F[8]=3.09; P=0.002) and dentate nucleus-to-pons (F[8]=2.36; pediatric brain on unenhanced
Pediatric Radiology – Springer Journals
Published: May 19, 2017
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