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- Publisher
- Springer Journals
- Copyright
- Copyright © 2010 by Nature Publishing Group
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Oncology
- ISSN
- 1759-4774
- eISSN
- 1759-4782
- DOI
- 10.1038/nrclinonc.2009.237
- Publisher site
- See Article on Publisher Site
Abstract
Microsatellite instability (MSI) is a frequent molecular phenomenon of colorectal cancer and is associated with deficient DNA mismatch repair. This Review presents an overview of MSI, including its clinical features and applications. The authors discuss the prognostic and predictive value of MSI and how it can be used to improve our knowledge of other cancer subtypes.
Journal
Nature Reviews Clinical Oncology – Springer Journals
Published: Feb 9, 2010