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Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFκB

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight... Research Article 693 Protection against hypoxia-induced increase in blood- brain barrier permeability: role of tight junction proteins and NFk B Rachel C. Brown, Karen S. Mark, Richard D. Egleton, Jason D. Huber, Amanda R. Burroughs and Thomas P. Davis* Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ, USA *Author for correspondence (e-mail: [email protected]) Accepted 8 November 2002 Journal of Cell Science 116, 693-700 © 2003 The Company of Biologists Ltd doi:10.1242/jcs.00264 Summary Co-culture with glial cells and glia-conditioned media can particularly in cells treated with C6-conditioned media. We induce blood-brain barrier properties in microvessel found that C6-conditioned media has a significantly higher endothelial cells and protect against hypoxia-induced level of both basic fibroblast growth factor and vascular blood-brain barrier breakdown. We examined the effect of endothelial growth factor. Treatment with C6-conditioned two types of glia-conditioned media on brain microvessel media for 1 or 3 days protects against hypoxia-induced endothelial cell permeability and tight junction protein permeability increases, and this protective effect may be expression, and studied potential mechanisms of action. We mediated by signal transduction pathways terminating at found that C6-glioma-conditioned media, but not rat the transcription factor NFk B. astrocyte-conditioned media, protected against an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cell Science Unpaywall

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFκB

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Unpaywall
ISSN
0021-9533
DOI
10.1242/jcs.00264
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Abstract

Research Article 693 Protection against hypoxia-induced increase in blood- brain barrier permeability: role of tight junction proteins and NFk B Rachel C. Brown, Karen S. Mark, Richard D. Egleton, Jason D. Huber, Amanda R. Burroughs and Thomas P. Davis* Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ, USA *Author for correspondence (e-mail: [email protected]) Accepted 8 November 2002 Journal of Cell Science 116, 693-700 © 2003 The Company of Biologists Ltd doi:10.1242/jcs.00264 Summary Co-culture with glial cells and glia-conditioned media can particularly in cells treated with C6-conditioned media. We induce blood-brain barrier properties in microvessel found that C6-conditioned media has a significantly higher endothelial cells and protect against hypoxia-induced level of both basic fibroblast growth factor and vascular blood-brain barrier breakdown. We examined the effect of endothelial growth factor. Treatment with C6-conditioned two types of glia-conditioned media on brain microvessel media for 1 or 3 days protects against hypoxia-induced endothelial cell permeability and tight junction protein permeability increases, and this protective effect may be expression, and studied potential mechanisms of action. We mediated by signal transduction pathways terminating at found that C6-glioma-conditioned media, but not rat the transcription factor NFk B. astrocyte-conditioned media, protected against an

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Journal of Cell Science – Unpaywall

Published: Feb 15, 2003

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