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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer-Verlag
- Subject
- Medicine & Public Health; Human Physiology ; Metabolic Diseases ; Internal Medicine
- ISSN
- 0012-186X
- eISSN
- 1432-0428
- DOI
- 10.1007/s00125-007-0914-7
- pmid
- 18219478
- Publisher site
- See Article on Publisher Site
Abstract
We showed direct evidence that GSK3β activity is associated with beta cell failure in diabetic mouse models and that its overactivation resulted in decreased pancreatic beta cell proliferation and mass. GSK3 modulates PDX-1 stability in both cultured insulinoma cells and islets in vivo. These results may ultimately facilitate the development of potential therapeutic interventions targeting type 2 diabetes and/or islet transplantation.
Journal
Diabetologia – Springer Journals
Published: Apr 1, 2008