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- Publisher
- The New England Journal of Medicine
- Copyright
- Copyright © 1996 Massachusetts Medical Society. All rights reserved.
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- DOI
- 10.1056/NEJM199610313351810
- pmid
- 8857025
- Publisher site
- See Article on Publisher Site
Abstract
The importance of insulin-like growth factor I (IGF-I) in regulating the effects of growth hormone on postnatal growth and development is well established, but its role during the prenatal period is not. Postnatally, the synthesis and release of IGF-I and its carriers — the IGF-binding proteins — are induced by the binding of growth hormone to its receptors in the liver. IGF-II, on the other hand, is not dependent on growth hormone. IGF-I acts by means of receptors for IGF-I and perhaps insulin, and IGF-II acts by means of a mannose-6-phosphate receptor. An understanding of how the system functions prenatally . . .
Journal
The New England Journal of Medicine – The New England Journal of Medicine
Published: Oct 31, 1996