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The Basal Ganglia VIIIOscillations in the Basal Ganglia: The good, the bad, and the unexpected

The Basal Ganglia VIII: Oscillations in the Basal Ganglia: The good, the bad, and the unexpected OSCILLATIONS IN THE BASAL GANGLIA: The good, the bad, and the unexpected Thomas Boraud, Peter Brown, Joshua A. Goldberg, Ann M. Graybiel, and Peter J. Magill* 1. INTRODUCTION Oscillations are present at many levels in the basal ganglia (BG), and can describe regular fluctuations in, for example, gene expression, current flow across the plasma mem- brane, the firing rate of a single neuron, the activity within and between small networks of neurons, and activity at the level of whole nuclei. Many BG neurons, including those of the subthalamic nucleus, globus pallidus (both segments), substantia nigra (both divisions), and some striatal interneurons, are endowed with a battery of intrinsic membrane properties that promote the expression of oscillatory discharge at both ‘rest’ (or in functional isolation) and in response to organized synaptic input (Richards et al., 1997; Bennett and Wilson, 1999; Bevan et al., 2002). The oscillatory activity of a single cell may or may not be syn- chronized with the oscillatory activity of another cell or network of cells. Indeed, oscillation and synchronization are distinct properties of neuronal networks. This is well illustrated in the BG; while the firing patterns of pallidal neurons are strongly periodic, the discharges of pairs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

The Basal Ganglia VIIIOscillations in the Basal Ganglia: The good, the bad, and the unexpected

Part of the Advances in Behavioral Biology Book Series (volume 56)
Editors: Bolam, J. Paul; Ingham, Cali A.; Magill, Peter J.
Boraud, Thomas; Brown, Peter; Goldberg, Joshua A.; Graybiel, Ann M.; Magill, Peter J.
The Basal Ganglia VIII — Jan 1, 2005
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References (97)

Publisher
Springer US
Copyright
© Springer Science+Business Media, Inc. 2005
ISBN
978-0-387-28065-3
Pages
1–24
DOI
10.1007/0-387-28066-9_1
Publisher site
See Chapter on Publisher Site

Abstract

OSCILLATIONS IN THE BASAL GANGLIA: The good, the bad, and the unexpected Thomas Boraud, Peter Brown, Joshua A. Goldberg, Ann M. Graybiel, and Peter J. Magill* 1. INTRODUCTION Oscillations are present at many levels in the basal ganglia (BG), and can describe regular fluctuations in, for example, gene expression, current flow across the plasma mem- brane, the firing rate of a single neuron, the activity within and between small networks of neurons, and activity at the level of whole nuclei. Many BG neurons, including those of the subthalamic nucleus, globus pallidus (both segments), substantia nigra (both divisions), and some striatal interneurons, are endowed with a battery of intrinsic membrane properties that promote the expression of oscillatory discharge at both ‘rest’ (or in functional isolation) and in response to organized synaptic input (Richards et al., 1997; Bennett and Wilson, 1999; Bevan et al., 2002). The oscillatory activity of a single cell may or may not be syn- chronized with the oscillatory activity of another cell or network of cells. Indeed, oscillation and synchronization are distinct properties of neuronal networks. This is well illustrated in the BG; while the firing patterns of pallidal neurons are strongly periodic, the discharges of pairs

Published: Jan 1, 2005

Keywords: Basal Ganglion; Spike Train; Subthalamic Nucleus; Oscillatory Activity; Beta Band

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