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Molecular Mechanisms Mediating Proliferation/Differentiation Interrelationships During Progressive Development of the Osteoblast Phenotype

Molecular Mechanisms Mediating Proliferation/Differentiation Interrelationships During... I. Introduction A FUNCTIONAL relationship between cell growth and the initiation and progression of events associated with differentiation has been a fundamental question challenging developmental biologists for more than a century. In the case of bone, as observed with other cells and tissue, the relationship of growth and differentiation must be maintained and stringently regulated, both during development and throughout the life of the organism, to support tissue remodeling. For many years, bone was defined anatomically and examined largely in a descriptive manner by ultrastructural analysis and by biochemical and histochemical methods. These studies provided the basis for our understanding of bone tissue organization and orchestration of the progressive recruitment, proliferation, and differentiation of the various cellular components of bone tissue. Now, complemented by an increased knowledge of molecular mechanisms that are associated with and regulate expression of genes encoding phenotypic components of bone, and those that may control the progressive development and maturation of the bone cell phenotype, our understanding of bone cell and tissue differentiation is rapidly expanding. This content is only available as a PDF. Copyright © 1993 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Endocrine Reviews Oxford University Press

Molecular Mechanisms Mediating Proliferation/Differentiation Interrelationships During Progressive Development of the Osteoblast Phenotype

Stein, Gary, S.; Lian, Jane, B.
Endocrine Reviews , Volume 14 (4) – Aug 1, 1993
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References (48)

Publisher
Oxford University Press
Copyright
Copyright © 1993 by The Endocrine Society
ISSN
0163-769X
eISSN
1945-7189
DOI
10.1210/edrv-14-4-424
pmid
8223340
Publisher site
See Article on Publisher Site

Abstract

I. Introduction A FUNCTIONAL relationship between cell growth and the initiation and progression of events associated with differentiation has been a fundamental question challenging developmental biologists for more than a century. In the case of bone, as observed with other cells and tissue, the relationship of growth and differentiation must be maintained and stringently regulated, both during development and throughout the life of the organism, to support tissue remodeling. For many years, bone was defined anatomically and examined largely in a descriptive manner by ultrastructural analysis and by biochemical and histochemical methods. These studies provided the basis for our understanding of bone tissue organization and orchestration of the progressive recruitment, proliferation, and differentiation of the various cellular components of bone tissue. Now, complemented by an increased knowledge of molecular mechanisms that are associated with and regulate expression of genes encoding phenotypic components of bone, and those that may control the progressive development and maturation of the bone cell phenotype, our understanding of bone cell and tissue differentiation is rapidly expanding. This content is only available as a PDF. Copyright © 1993 by The Endocrine Society

Journal

Endocrine Reviews – Oxford University Press

Published: Aug 1, 1993

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