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References (144)
-
M. Kavurma, N. Figg, M. Bennett, J. Mercer, L. Khachigian, T. Littlewood (2007)
Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment.The Biochemical journal, 407 1
-
Z. Saifudeen, Jessica Marks, H. Du, S. El-Dahr (2002)
Spatial repression of PCNA by p53 during kidney development.American journal of physiology. Renal physiology, 283 4
-
W. El-Deiry, S. Kern, J. Pietenpol, K. Kinzler, B. Vogelstein (1992)
Definition of a consensus binding site for p53Nature Genetics, 1
-
Tsung-Cheng Chang, E. Wentzel, O. Kent, Kalyani Ramachandran, M. Mullendore, K. Lee, G. Feldmann, M. Yamakuchi, M. Ferlito, C. Lowenstein, D. Arking, Michael Beer, A. Maitra, J. Mendell (2007)
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.Molecular cell, 26 5
-
K. Spurgers, D. Gold, K. Coombes, Nicole Bohnenstiehl, B. Mullins, R. Meyn, C. Logothetis, T. McDonnell (2006)
Identification of Cell Cycle Regulatory Genes as Principal Targets of p53-mediated Transcriptional Repression*Journal of Biological Chemistry, 281
-
H. Werner, E. Karnieli, F. Rauscher, D. Leroith (1996)
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.Proceedings of the National Academy of Sciences of the United States of America, 93 16
-
Kangjian Wu, Shi-Wen Jiang, F. Couch (2003)
p53 Mediates Repression of the BRCA2 Promoter and Down-regulation of BRCA2 mRNA and Protein Levels in Response to DNA Damage*The Journal of Biological Chemistry, 278
-
H. Hermeking, C. Lengauer, K. Polyak, T. He, L. Zhang, S. Thiagalingam, K. Kinzler, B. Vogelstein (1997)
14-3-3sigma is a p53-regulated inhibitor of G2/M progression.Molecular cell, 1 1
-
Baoqing Li, Marietta Lee (2001)
Transcriptional Regulation of the Human DNA Polymerase δ Catalytic Subunit Gene POLD1 by p53 Tumor Suppressor and Sp1*The Journal of Biological Chemistry, 276
-
Yun Wang, J. Schwedes, Dorothy Parks, Kristine Mann, P. Tegtmeyer (1995)
Interaction of p53 with its consensus DNA-binding siteMolecular and Cellular Biology, 15
-
S. Dhar, Yong Xu, Yumin Chen, D. Clair (2006)
Specificity Protein 1-dependent p53-mediated Suppression of Human Manganese Superoxide Dismutase Gene Expression*Journal of Biological Chemistry, 281
-
B. Ding, J. Whetstine, T. Witt, J. Schuetz, L. Matherly (2001)
Repression of Human Reduced Folate Carrier Gene Expression by Wild Type p53*The Journal of Biological Chemistry, 276
-
P. Estève, H. Chin, S. Pradhan (2005)
Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters.Proceedings of the National Academy of Sciences of the United States of America, 102 4
-
S. Sciacchitano, A. Orecchio, L. Lavra, S. Misiti, A. Giacchini, M. Zani, D. Danese, A. Gurtner, S. Soddu, U. Mario, M. Andreoli (2002)
Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.Molecular endocrinology, 16 7
-
S. Godár, T. Ince, G. Bell, D. Feldser, Joana Donaher, J. Bergh, Ann Liu, Kevin Miu, R. Watnick, Ferenc Reinhardt, S. McAllister, T. Jacks, R. Weinberg (2008)
Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 ExpressionCell, 134
-
Y. Lee, Y. Chen, L. Chang, L. Johnson (1997)
Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein.Experimental cell research, 234 2
-
DW Zhang, K. Jeang, Cgl Lee (2006)
p53 negatively regulates the expression of FAT10, a gene upregulated in various cancersOncogene, 25
-
Kazutoshi Takahashi, K. Tanabe, M. Ohnuki, Megumi Narita, T. Ichisaka, K. Tomoda, S. Yamanaka (2007)
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 131
-
Selvon Clair, L. Giono, S. Varmeh-Ziaie, L. Resnick-Silverman, Wen-jun Liu, Abhilash Padi, Jayasri Dastidar, Andrea DaCosta, M. Mattia, J. Manfredi (2004)
DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.Molecular cell, 16 5
-
P. Kho, Zhen Wang, Zhuang Li, Yuqing Li, Joon-Lin Chew, H. Ng, E. Liu, Qiang Yu (2004)
p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis*Journal of Biological Chemistry, 279
-
L. Harris, J. Remack, P. Houghton, T. Brent (1996)
Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.Cancer research, 56 9
-
P. Arizti, Li Fang, Iha Park, Yuxin Yin, E. Solomon, T. Ouchi, S. Aaronson, Sam Lee (2000)
Tumor Suppressor p53 Is Required To Modulate BRCA1 ExpressionMolecular and Cellular Biology, 20
-
K. Scully, E. Jacobson, Kristen Jepsen, V. Lunyak, H. Viadiu, C. Carrière, D. Rose, F. Hooshmand, A. Aggarwal, M. Rosenfeld (2000)
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification.Science, 290 5494
-
Xiaobin Han, A. Patters, R. Chesney (2002)
Transcriptional Repression of Taurine Transporter Gene (TauT) by p53 in Renal Cells*The Journal of Biological Chemistry, 277
-
A. Scoumanne, Xinbin Chen (2006)
The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition.Cancer research, 66 12
-
F. Alimirah, R. Panchanathan, Jianming Chen, Xiang Zhang, S. Ho, D. Choubey (2007)
Expression of androgen receptor is negatively regulated by p53.Neoplasia, 9 12
-
P. Wilson, W. Fazzone, M. LaBonte, H. Lenz, R. Ladner (2008)
Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damageNucleic Acids Research, 37
-
Lin He, Xingyue He, Lee Lim, E. Stanchina, Zhenyu Xuan, Yu Liang, W. Xue, L. Zender, Jill Magnus, Dana Ridzon, A. Jackson, P. Linsley, Caifu Chen, S. Lowe, M. Cleary, G. Hannon (2007)
A microRNA component of the p53 tumour suppressor networkNature, 447
-
I. Manni, Giuseppina Mazzaro, A. Gurtner, R. Mantovani, U. Haugwitz, K. Krause, K. Engeland, A. Sacchi, S. Soddu, G. Piaggio (2001)
NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest*The Journal of Biological Chemistry, 276
-
S. Kubicka, Florian Kühnel, L. Zender, K. Rudolph, J. Plümpe, Michael Manns, C. Trautwein (1999)
p53 Represses CAAT Enhancer-binding Protein (C/EBP)-dependent Transcription of the Albumin GeneThe Journal of Biological Chemistry, 274
-
D. Raj, Tong Liu, G. Samadashwily, Fengzhi Li, D. Grossman (2008)
Survivin repression by p53, Rb and E2F2 in normal human melanocytes.Carcinogenesis, 29 1
-
M. Pastorcic, H. Das (2000)
Regulation of Transcription of the Human Presenilin-1 Gene by Ets Transcription Factors and the p53 Protooncogene*The Journal of Biological Chemistry, 275
-
A. Barsotti, C. Prives (2009)
Pro-proliferative FoxM1 is a target of p53-mediated repressionOncogene, 28
-
K. Mortensen, J. Skouv, D. Hougaard, L. Larsson (1999)
Endogenous Endothelial Cell Nitric-oxide Synthase Modulates Apoptosis in Cultured Breast Cancer Cells and Is Transcriptionally Regulated by p53*The Journal of Biological Chemistry, 274
-
Taraswi Banerjee, Somsubhra Nath, S. Roychoudhury (2009)
DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodelingNucleic Acids Research, 37
-
G. Qin, R. Kishore, Christine Dolan, Marcy Silver, A. Wecker, Corinne Luedemann, T. Thorne, A. Hanley, C. Curry, Lindsay Heyd, D. Dinesh, M. Kearney, F. Martelli, T. Murayama, D. Goukassian, Yan Zhu, Douglas Losordo (2006)
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.Proceedings of the National Academy of Sciences of the United States of America, 103 29
-
Nina Raver-Shapira, M. Oren (2007)
Tiny Actors, Great Roles: microRNAs in p53's ServiceCell Cycle, 6
-
Jeffrey Lefstin, K. Yamamoto (1998)
Allosteric effects of DNA on transcriptional regulatorsNature, 392
-
A. Maiyar, P. Phu, A. Huang, G. Firestone (1997)
Repression of glucocorticoid receptor transactivation and DNA binding of a glucocorticoid response element within the serum/glucocorticoid-inducible protein kinase (sgk) gene promoter by the p53 tumor suppressor protein.Molecular endocrinology, 11 3
-
K. Robertson, Peter Jones (1998)
The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53Molecular and Cellular Biology, 18
-
Martin Smith, I. Chen, Q. Zhan, I. Bae, C.–Y. Chen, T. Gilmer, M. Kastan, P. O'Connor, A. Fornace (1994)
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.Science, 266 5189
-
N. Kley, R. Chung, S. Fay, J. Loeffler, B. Seizinger (1992)
Repression of the basal c-fos promoter by wild-type p53.Nucleic acids research, 20 15
-
(1999)
p53 downregulates human matrix metalloproteinase-1 (Collagenase-1) gene expression -
J. Johnsen, O. Aurelio, Zeenat Kwaja, Gunn Jörgensen, N. Pellegata, R. Plattner, E. Stanbridge, J. Cajot (2000)
p53‐mediated negative regulation of stathmin/Op18 expression is associated with G2/M cell‐cycle arrestInternational Journal of Cancer, 88
-
W. Hsieh, S. Hsieh, Chia-Chen Chen, F. Wang (2008)
Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage.Biochemical and biophysical research communications, 369 2
-
Y. Xiong, G. Hannon, Hui Zhang, D. Casso, R. Kobayashi, D. Beach (1993)
p21 is a universal inhibitor of cyclin kinasesNature, 366
-
N. Zhu, L. Gu, H. Findley, Mu-xiang Zhou (2005)
Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53.Biochemical and biophysical research communications, 335 4
-
E. Appella, C. Anderson (2001)
Post-translational modifications and activation of p53 by genotoxic stresses.European journal of biochemistry, 268 10
-
Bei Wang, P. Feng, Ziwei Xiao, E. Ren (2009)
LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.Journal of hepatology, 50 3
-
Jun Li, M. Tan, Ling-Hao Li, D. Pamarthy, T. Lawrence, Yi Sun (2005)
SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing.Neoplasia, 7 4
-
D. Lin, Chawnshang Chang (1996)
p53 Is a Mediator for Radiation-repressed Human TR2 Orphan Receptor Expression in MCF-7 Cells, a New Pathway from Tumor Suppressor to Member of the Steroid Receptor Superfamily*The Journal of Biological Chemistry, 271
-
Lin He, Xingyue He, S. Lowe, G. Hannon (2007)
microRNAs join the p53 network — another piece in the tumour-suppression puzzleNature Reviews Cancer, 7
-
J. Ho, Weili Ma, Daniel Mao, S. Benchimol (2005)
p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle ArrestMolecular and Cellular Biology, 25
-
Manuel Rodríguez, J. Desterro, S. Laín, C. Midgley, D. Lane, R. Hay (1999)
SUMO‐1 modification activates the transcriptional response of p53The EMBO Journal, 18
-
Hong-li Yan, G. Xue, Q. Mei, Yu‐zhao Wang, Fei-xiang Ding, Mohan Liu, Ming-hua Lu, Ying Tang, Hong-yu Yu, Shuhan Sun (2009)
Repression of the miR‐17‐92 cluster by p53 has an important function in hypoxia‐induced apoptosisThe EMBO Journal, 28
-
D. Menendez, Oliver Krysiak, A. Inga, Bianca Krysiak, M. Resnick, G. Schönfelder (2006)
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional networkProceedings of the National Academy of Sciences of the United States of America, 103
-
C. Imbriano, A. Gurtner, F. Cocchiarella, Silvia Agostino, V. Basile, M. Gostissa, M. Dobbelstein, G. Sal, G. Piaggio, R. Mantovani (2005)
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M PromotersMolecular and Cellular Biology, 25
-
Thi Nguyen, Kyucheol Cho, S. Stratton, M. Barton (2005)
Transcription Factor Interactions and Chromatin Modifications Associated with p53-Mediated, Developmental Repression of the Alpha-Fetoprotein GeneMolecular and Cellular Biology, 25
-
Zoltán Oltval, C. Milliman, S. Korsmeyer (1993)
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell deathCell, 74
-
G. Gac, P. Estève, C. Férec, S. Pradhan (2006)
DNA Damage-induced Down-regulation of Human Cdc25C and Cdc2 Is Mediated by Cooperation between p53 and Maintenance DNA (Cytosine-5) Methyltransferase 1*Journal of Biological Chemistry, 281
-
William Hoffman, S. Biade, J. Zilfou, Jiandong Chen, M. Murphy (2002)
Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53*The Journal of Biological Chemistry, 277
-
Diederik Bodegom, Z. Saifudeen, S. Dipp, S. Puri, B. Magenheimer, J. Calvet, S. El-Dahr (2006)
The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression*Journal of Biological Chemistry, 281
-
(1996)
Tumor suppressor p53 downregulates tissue-specific expression of tyrosinase gene in human melanoma cell lines -
Z. Sherif, S. Nakai, K. Pirollo, A. Rait, E. Chang (2001)
Downmodulation of bFGF-binding protein expression following restoration of p53 functionCancer Gene Therapy, 8
-
Yubo Sun, J. Cheung, Joanne Martel-Pelletier, J. Pelletier, L. Wenger, R. Altman, D. Howell, H. Cheung (2000)
Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)*The Journal of Biological Chemistry, 275
-
Printed in U.S.A. Copyright © 1998 by The Endocrine Society p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1 -
V. Tarasov, P. Jung, B. Verdoodt, D. Lodygin, A. Epanchintsev, A. Menssen, G. Meister, H. Hermeking (2007)
Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrestCell Cycle, 6
-
J. Cook, R. Re, J. Giardina, Fontenot Fe, Cheng Dy, J. Alam (1995)
Distance constraints and stereospecific alignment requirements characteristic of p53 DNA-binding consensus sequence homologies.Oncogene, 11 4
-
Nina Raver-Shapira, E. Marciano, E. Meiri, Y. Spector, N. Rosenfeld, N. Moskovits, Z. Bentwich, M. Oren (2007)
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.Molecular cell, 26 5
-
M. Gostissa, Arnd Hengstermann, V. Fogal, P. Sandy, Sylvia Schwarz, M. Scheffner, G. Sal (1999)
Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1The EMBO Journal, 18
-
Angelo Cicalese, G. Bonizzi, C. Pasi, M. Faretta, S. Ronzoni, B. Giulini, C. Brisken, S. Minucci, P. Fiore, P. Pelicci (2009)
The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem CellsCell, 138
-
K. Vousden, K. Ryan (2009)
p53 and metabolismNature Reviews Cancer, 9
-
Tomohide Kidokoro, C. Tanikawa, Y. Furukawa, T. Katagiri, Y. Nakamura, K. Matsuda (2008)
CDC20, a potential cancer therapeutic target, is negatively regulated by p53Oncogene, 27
-
Ella Kim, W. Günther, K. Yoshizato, H. Meissner, S. Zapf, R. Nüsing, Hirotaka Yamamoto, Erwin Meir, W. Deppert, A. Giese (2003)
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1Oncogene, 22
-
N. Osifchin, Di Jiang, N. Ohtani‐Fujita, T. Fujita, Michael Carroza, Seong-Jin Kim, Toshiyuki Sakai, Paul Robbins (1994)
Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.The Journal of biological chemistry, 269 9
-
R. Johnson, T. Ince, K. Scotto (2001)
Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element* 210The Journal of Biological Chemistry, 276
-
Bulbul Pandit, M. Halasi, A. Gartel (2009)
p53 negatively regulates expression of FoxM1Cell Cycle, 8
-
Hyenjong Hong, Kazutoshi Takahashi, T. Ichisaka, T. Aoi, O. Kanagawa, M. Nakagawa, K. Okita, S. Yamanaka (2009)
Suppression of induced pluripotent stem cell generation by the p53–p21 pathwayNature, 460
-
J. Wong, Pei-Xiang Li, H. Klamut (2002)
A Novel p53 Transcriptional Repressor Element (p53TRE) and the Asymmetrical Contribution of Two p53 Binding Sites Modulate the Response of the Placental Transforming Growth Factor-β Promoter to p53*The Journal of Biological Chemistry, 277
-
N. Sankpal, Mike Willman, T. Fleming, J. Mayfield, W. Gillanders (2009)
Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion.Cancer research, 69 3
-
Z. Salah, S. Haupt, M. Maoz, L. Baraz, V. Rotter, T. Peretz, Y. Haupt, R. Bar-Shavit (2008)
p53 controls hPar1 function and expressionOncogene, 27
-
S. Agoff, J. Hou, D. Linzer, B. Wu (1993)
Regulation of the human hsp70 promoter by p53.Science, 259 5091
-
J. Espinosa, B. Emerson (2001)
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.Molecular cell, 8 1
-
S. Sengupta, A. Shimamoto, M. Koshiji, R. Pedeux, M. Rusin, M. Rusin, E. Spillare, Jiang-Cheng Shen, L. Huang, N. Lindor, Y. Furuichi, C. Harris (2005)
Tumor suppressor p53 represses transcription of RECQ4 helicaseOncogene, 24
-
Assaf Ori, Arie Zauberman, G. Doitsh, N. Paran, M. Oren, Y. Shaul (1998)
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53The EMBO Journal, 17
-
Ye Zhang, Jin-shan Wang, Li-Ling Chen, Yong Zhang, Xiao-kuan Cheng, F. Heng, N. Wu, Yu‐fei Shen (2004)
Repression of hsp90β Gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells*Journal of Biological Chemistry, 279
-
Junying Yu, M. Vodyanik, K. Smuga-Otto, Jessica Antosiewicz-Bourget, Jennifer Frane, Shulan Tian, Jeff Nie, Gudrun Jonsdottir, Victor Ruotti, R. Stewart, I. Slukvin, J. Thomson (2007)
Induced Pluripotent Stem Cell Lines Derived from Human Somatic CellsScience, 318
-
E. Peterson, O. Bögler, Shirley Taylor (2003)
p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.Cancer research, 63 20
-
N. Webster, J. Resnik, D. Reichart, B. Strauss, M. Haas, B. Seely (1996)
Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.Cancer research, 56 12
-
M. Murphy, Jaimo Ahn, Kristen Walker, William Hoffman, R. Evans, A. Levine, D. George (1999)
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Genes & development, 13 19
-
C. Arias-López, I. Lazaro-Trueba, P. Kerr, C. Lord, T. Dexter, M. Iravani, A. Ashworth, Augusto Silva (2006)
p53 modulates homologous recombination by transcriptional regulation of the RAD51 geneEMBO reports, 7
-
Chantal Desdouets, Catherine Ory, Graziella Matesic, Thierry Soussi, Christian Bréchot, J. Sobczak-Thépot (1996)
ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoterFEBS Letters, 385
-
Bei Wang, Ziwei Xiao, E. Ren (2009)
Redefining the p53 response elementProceedings of the National Academy of Sciences, 106
-
S. Innocente, Jonathan Lee (2005)
p53 is a NF‐Y‐ and p21‐independent, Sp1‐dependent repressor of cyclin B1 transcriptionFEBS Letters, 579
-
S. D’Souza, H. Xin, S. Walter, D. Choubey (2001)
The Gene Encoding p202, an Interferon-inducible Negative Regulator of the p53 Tumor Suppressor, Is a Target of p53-mediated Transcriptional Repression*The Journal of Biological Chemistry, 276
-
(2009)
Linking the p53 tumour suppressor pathway to somatic cell reprogramming -
M. Modugno, E. Tagliabue, E. Ardini, V. Berno, E. Galmozzi, M. Bortoli, V. Castronovo, S. Ménard (2002)
p53-dependent downregulation of metastasis-associated laminin receptorOncogene, 21
-
J. Yun, H. Chae, H. Choy, Jongkyeong Chung, H. Yoo, Moonjoo Han, Deug Shin (1999)
p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor*The Journal of Biological Chemistry, 274
-
Xueying Wang, Hui-Yi Kua, Yuanyu Hu, Ke Guo, Q. Zeng, Qiang Wu, H. Ng, G. Karsenty, B. Crombrugghe, J. Yeh, Baojie Li (2006)
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodelingThe Journal of Cell Biology, 172
-
Yutaka Maeda, Wendy Hwang-Verslues, Gang Wei, T. Fukazawa, M. Durbin, L. Owen, Xuan Liu, F. Sladek (2006)
Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.The Biochemical journal, 400 2
-
Ximena Montano, Ximena Montano (2009)
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferationOncogene, 28
-
R. Faraonio, P. Vergara, Domenico Marzo, M. Pierantoni, M. Napolitano, T. Russo, F. Cimino (2006)
p53 Suppresses the Nrf2-dependent Transcription of Antioxidant Response Genes*Journal of Biological Chemistry, 281
-
M. Sachdeva, Shoumin Zhu, Fangting Wu, Hailong Wu, Vijay Walia, Sumit Kumar, R. Elble, K. Watabe, Y. Mo (2009)
p53 represses c-Myc through induction of the tumor suppressor miR-145Proceedings of the National Academy of Sciences, 106
-
A. Zaky, C. Busso, T. Izumi, Ranajoy Chattopadhyay, A. Bassiouny, S. Mitra, K. Bhakat (2008)
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damageNucleic Acids Research, 36
-
Todd Riley, Eduardo Sontag, Patricia Chen, A. Levine (2008)
Transcriptional control of human p53-regulated genesNature Reviews Molecular Cell Biology, 9
-
J. Huvos (1975)
Federal Republic of GermanyIntereconomics, 10
-
Takashi Tokino, Sam Thiagalingam, W. El-Deiry, Todd Waldman, K. Kinzler, B. Vogelstein (1994)
p53 tagged sites from human genomic DNA.Human molecular genetics, 3 9
-
H. Hermeking (2007)
p53 enters the microRNA world.Cancer cell, 12 5
-
J. Raimond, F. Rouleux, M. Monsigny, A. Legrand (1995)
The second intron of the human galectin‐3 gene has a strong promoter activity down‐regulated by p53FEBS Letters, 363
-
K. Krause, M. Wasner, Wibke Reinhard, U. Haugwitz, Christine Dohna, Joachim Mössner, K. Engeland (2000)
The tumour suppressor protein p53 can repress transcription of cyclin B.Nucleic acids research, 28 22
-
P. Stanhope-Baker, P. Kessler, Wenliang Li, M. Agarwal, Bryan Williams (2004)
The Wilms Tumor Suppressor-1 Target Gene Podocalyxin Is Transcriptionally Repressed by p53*Journal of Biological Chemistry, 279
-
Yu-Ling Wu, John Mehew, C. Heckman, M. Arcinas, L. Boxer (2001)
Negative regulation of bcl-2 expression by p53 in hematopoietic cellsOncogene, 20
-
Cong Li, Meihong Lin, Jingwen Liu (2004)
Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesisOncogene, 23
-
A. Mirza, Qun Wu, Luquan Wang, T. Mcclanahan, W. Bishop, F. Gheyas, Wei Ding, B. Hutchins, Tish Hockenberry, P. Kirschmeier, Jonathan Greene, Suxing Liu (2003)
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progressionOncogene, 22
-
W. Lowry, Laura Richter, Robin Yachechko, A. Pyle, J. Tchieu, Rupa Sridharan, A. Clark, K. Plath (2008)
Generation of human induced pluripotent stem cells from dermal fibroblastsProceedings of the National Academy of Sciences, 105
-
M. Sandri, R. Isaacs, W. Ongkeko, A. Harris, I. Hickson, M. Broggini, F. Vikhanskaya (1996)
p53 regulates the minimal promoter of the human topoisomerase IIalpha gene.Nucleic acids research, 24 22
-
Kathleen Lee, A. Crowe, M. Barton (1999)
p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA BindingMolecular and Cellular Biology, 19
-
FJ Geske, AC Nelson, R. Lieberman, R. Strange, T. Sun, LE Gerschenson (2000)
DNA repair is activated in early stages of p53-induced apoptosisCell Death and Differentiation, 7
-
V. Golubovskaya, Aparna Kaur, W. Cance (2004)
Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites.Biochimica et biophysica acta, 1678 2-3
-
In-Hyun Park, Rui Zhao, Jason West, A. Yabuuchi, Hongguang Huo, Tan Ince, P. Lerou, M. Lensch, George Daley (2008)
Reprogramming of human somatic cells to pluripotency with defined factorsNature, 451
-
Maocheng Zhan, Dihua Yu, Juehui Liu, J. Hannay, R. Pollock (2005)
Transcriptional Repression of Protein Kinase Cα via Sp1 by Wild Type p53 Is Involved in Inhibition of Multidrug Resistance 1 P-Glycoprotein Phosphorylation*Journal of Biological Chemistry, 280
-
Tongxiang Lin, C. Chao, Shinichi Saito, S. Mazur, M. Murphy, E. Appella, Yang Xu (2005)
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionNature Cell Biology, 7
-
W. Mercer, M. Shields, D. Lin, E. Appella, S. Ullrich (1991)
Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.Proceedings of the National Academy of Sciences of the United States of America, 88 5
-
Mika Inomata, H. Tagawa, Yong-Mei Guo, Y. Kameoka, N. Takahashi, K. Sawada (2008)
MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes.Blood, 113 2
-
Lianglin Zhang, Dihua Yu, Mei Hu, Shunbin Xiong, A. Lang, Lee Ellis, Raphael Pollock (2000)
Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression.Cancer research, 60 13
-
K. Subbaramaiah, N. Altorki, W. Chung, J. Mestre, Anu Sampat, A. Dannenberg (1999)
Inhibition of Cyclooxygenase-2 Gene Expression by p53*The Journal of Biological Chemistry, 274
-
K. Krause, U. Haugwitz, M. Wasner, M. Wiedmann, J. Mössner, K. Engeland (2001)
Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73.Biochemical and biophysical research communications, 284 3
-
U. Santhanam, A. Ray, P. Sehgal (1991)
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.Proceedings of the National Academy of Sciences of the United States of America, 88 17
-
Yu-Zhen Li, Daoyuan Lu, W. Tan, Jian-Xun Wang, Peilong Li (2007)
p53 Initiates Apoptosis by Transcriptionally Targeting the Antiapoptotic Protein ARCMolecular and Cellular Biology, 28
-
Hiroshi Suzuki, K. Yamagata, K. Sugimoto, T. Iwamoto, S. Kato, K. Miyazono (2009)
Modulation of microRNA processing by p53Nature, 460
-
J. Jordan, D. Menendez, A. Inga, Maher Nourredine, D. Bell, M. Resnick (2008)
Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53PLoS Genetics, 4
-
M. Griffioen, W. Steegenga, I. Ouwerkerk, L. Peltenburg, A. Jochemsen, P. Schrier (1998)
Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms.Molecular immunology, 35 13
-
D. Menendez, A. Inga, M. Resnick (2009)
The expanding universe of p53 targetsNature Reviews Cancer, 9
-
V. Budhram-Mahadeo, P. Morris, M. Smith, C. Midgley, L. Boxer, D. Latchman (1999)
p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor*The Journal of Biological Chemistry, 274
-
(1996)
Wild-type p53 negatively regulates the expression of a microtubuleassociated protein -
Y. Shiio, T. Yamamoto, N. Yamaguchi (1992)
Negative regulation of Rb expression by the p53 gene product.Proceedings of the National Academy of Sciences of the United States of America, 89
-
F. Fornari, L. Gramantieri, C. Giovannini, A. Veronese, M. Ferracin, S. Sabbioni, G. Calin, G. Grazi, C. Croce, S. Tavolari, P. Chieco, M. Negrini, L. Bolondi (2009)
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.Cancer research, 69 14
-
M. Le, C. Teh, Ng Shyh‐Chang, Huangming Xie, Beiyan Zhou, V. Korzh, H. Lodish, B. Lim (2009)
MicroRNA-125b is a novel negative regulator of p53.Genes & development, 23 7
-
(2000)
PTGFbeta, a type beta transforming growth factor (TGFbeta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGFbeta signaling pathway -
K. Bensaad, A. Tsuruta, M. Selak, M. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, K. Vousden (2006)
TIGAR, a p53-Inducible Regulator of Glycolysis and ApoptosisCell, 126
-
H. Im, M. Pittelkow, R. Kumar (2002)
Divergent Regulation of the Growth-promoting GeneIEX-1 by the p53 Tumor Suppressor and Sp1*The Journal of Biological Chemistry, 277
-
T. Miyashita, M. Harigai, M. Hanada, John Reed (1994)
Identification of a p53-dependent negative response element in the bcl-2 gene.Cancer research, 54 12
-
Abel Chun, D. Jin (2003)
Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53*Journal of Biological Chemistry, 278
-
T. Kanaya, S. Kyo, K. Hamada, M. Takakura, Y. Kitagawa, H. Harada, M. Inoue (2000)
Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.Clinical cancer research : an official journal of the American Association for Cancer Research, 6 4
- Publisher
- Taylor & Francis
- Copyright
- Copyright © 2010 Landes Bioscience
- ISSN
- 1551-4005
- eISSN
- 1538-4101
- DOI
- 10.4161/cc.9.5.10825
- pmid
- 20160511
- Publisher site
- See Article on Publisher Site
Abstract
p53 tumor suppressor has been widely recognized as the "Guardian of the Genome", reflecting its importance in ensuring the proper functioning of the cell. It is well-known for its function as a transcription factor, capable of mediating both transcriptional activation and repression, which brings about many cellular outcomes such as cell-cycle arrest, apoptosis, cellular senescence and DNA repair. The canonical p53 response element (p53RE), which contains two repeats of a decamer motif "RRRCWWGYYY" separated by a spacer of 0 to 13 base-pairs, has been characterized as the regulatory region on the target genes that p53 binds for transcriptional activation. It was thought that p53 generally represses genes that lack this canonical p53RE, presumably through the sequestration of basal transcriptional machinery components or transcription activators. However, characterization of individual genes as well as genome-wide studies utilizing gene expression profiling and chromatin immunoprecipitation uncovered a large number of potential p53-repressed targets. Taken together, there appears to be multiple modes of gene repression by p53 with some being mediated through direct binding of p53 to DNA. The aim of this review is to assess the evidence of p53 mediated transcriptional repression and discuss its role in cellular function.
Journal
Cell Cycle – Taylor & Francis
Published: Mar 1, 2010