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Inflammasomes in the CNS

Inflammasomes in the CNS 'Inflammasomes' are intracellular protein complexes, which function as sensors for infectious or injurious stimuli and enable innate immune responses. They are increasingly being recognized as determinants of CNS diseases. Inflammasome aggregation and activation result in the maturation and extracellular release of the cytokines interleukin-1β (IL-1β) and IL-18, largely from mononuclear phagocytic cells of the CNS such as microglia, but inflammasome formation in neurons is being increasingly appreciated. Inflammasome activation, particularly the NOD-, LRR- and pyrin domain-containing 3 (NLPR3) inflammasome, has been reported across a broad spectrum of CNS diseases, including acute bacterial or viral infections, sterile injuries such as stroke and in chronic diseases such as Alzheimer's disease and multiple sclerosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Neuroscience Springer Journals

Inflammasomes in the CNS

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References (160)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
ISSN
1471-003X
eISSN
1471-0048
DOI
10.1038/nrn3638
Publisher site
See Article on Publisher Site

Abstract

'Inflammasomes' are intracellular protein complexes, which function as sensors for infectious or injurious stimuli and enable innate immune responses. They are increasingly being recognized as determinants of CNS diseases. Inflammasome aggregation and activation result in the maturation and extracellular release of the cytokines interleukin-1β (IL-1β) and IL-18, largely from mononuclear phagocytic cells of the CNS such as microglia, but inflammasome formation in neurons is being increasingly appreciated. Inflammasome activation, particularly the NOD-, LRR- and pyrin domain-containing 3 (NLPR3) inflammasome, has been reported across a broad spectrum of CNS diseases, including acute bacterial or viral infections, sterile injuries such as stroke and in chronic diseases such as Alzheimer's disease and multiple sclerosis.

Journal

Nature Reviews Neuroscience – Springer Journals

Published: Jan 8, 2014

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