-
Y.
Ishikawa,
Masaki
Hosogane,
Ryuhei
Okuyama,
S.
Aoyama,
I.
Onoyama,
Keiichi
Nakayama,
Keiko
Nakayama
(2013)
Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch
Oncogene, 32
-
E.
Nishimura,
S.
Granter,
D.
Fisher
(2005)
Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche
Science, 307
-
S.
Heilmann,
A.
Kiefer,
Nadine
Fricker,
D.
Drichel,
A.
Hillmer,
C.
Herold,
J.
Tung,
N.
Eriksson,
S.
Redler,
R.
Betz,
Rui
Li,
Ari
Kárason,
D.
Nyholt,
Kijoung
Song,
S.
Vermeulen,
S.
Kanoni,
G.
Dedoussis,
N.
Martin,
L.
Kiemeney,
V.
Mooser,
K.
Stefánsson,
J.
Richards,
T.
Becker,
F.
Brockschmidt,
D.
Hinds,
M.
Nöthen
(2013)
Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.
The Journal of investigative dermatology, 133 6
-
Mayumi
Ito,
K.
Kizawa,
K.
Hamada,
G.
Cotsarelis
(2004)
Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen.
Differentiation; research in biological diversity, 72 9-10
-
Claus-Werner
Franzke,
K.
Tasanen,
H.
Schäcke,
Zhongjun
Zhou,
K.
Tryggvason,
C.
Mauch,
P.
Zigrino,
S.
Sunnarborg,
David
Lee,
F.
Fahrenholz,
L.
Bruckner-Tuderman
(2002)
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
The EMBO Journal, 21
-
L.
Partridge,
D.
Gems
(2002)
Mechanisms of aging: public or private?
Nature Reviews Genetics, 3
-
J.
Doles,
M.
Storer,
L.
Cozzuto,
G.
Roma,
W.
Keyes
(2012)
Age-associated inflammation inhibits epidermal stem cell function.
Genes & development, 26 19
-
Mayumi
Ito,
Yaping
Liu,
Zaixin
Yang,
Jane
Nguyen,
Fan
Liang,
R.
Morris,
G.
Cotsarelis
(2005)
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
Nature Medicine, 11
-
G.
Cotsarelis,
T.
Sun,
R.
Lavker
(1990)
Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
Cell, 61
-
A.
Hofer,
Rosie
Tran,
Owais
Aziz,
W.
Wright,
G.
Novelli,
J.
Shay,
Marc
Lewis
(2005)
Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging.
The journals of gerontology. Series A, Biological sciences and medical sciences, 60 1
-
Tapan
Bhattacharyya,
J.
Thomas
(2004)
Histomorphologic changes in aging skin: observations in the CBA mouse model.
Archives of facial plastic surgery, 6 1
-
W.
Lowry,
C.
Blanpain,
J.
Nowak,
Géraldine
Guasch,
L.
Lewis,
E.
Fuchs
(2005)
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.
Genes & development, 19 13
-
M.
Ohyama,
A.
Terunuma,
C.
Tock,
M.
Radonovich,
C.
Pise-Masison,
S.
Hopping,
J.
Brady,
M.
Udey,
J.
Vogel
(2005)
Characterization and isolation of stem cell-enriched human hair follicle bulge cells.
The Journal of clinical investigation, 116 1
-
J.
Boer,
Jaan-Olle
Andressoo,
J.
Wit,
J.
Huijmans,
R.
Beems,
H.
Steeg,
G.
Weeda,
G.
Horst,
Wibeke
Leeuwen,
A.
Themmen,
M.
Meradji,
J.
Hoeijmakers
(2002)
Premature Aging in Mice Deficient in DNA Repair and Transcription
Science, 296
-
L.
Guarente,
C.
Kenyon
(2000)
Genetic pathways that regulate ageing in model organisms
Nature, 408
-
Elisabete
Nascimento,
C.
Cox,
S.
MacArthur,
S.
Hussain,
M.
Trotter,
S.
Blanco,
Menon
Suraj,
J.
Nichols,
B.
Kübler,
S.
Benitah,
B.
Hendrich,
D.
Odom,
M.
Frye
(2011)
The opposing transcriptional functions of Sin3A and c-Myc are required to maintain tissue homeostasis
Nature cell biology, 13
-
Claus-Werner
Franzke,
L.
Bruckner-Tuderman,
C.
Blobel
(2009)
Shedding of Collagen XVII/BP180 in Skin Depends on Both ADAM10 and ADAM9*
The Journal of Biological Chemistry, 284
-
A.
Giangreco,
M.
Qin,
J.
Pintar,
F.
Watt
(2008)
Epidermal stem cells are retained in vivo throughout skin aging
Aging Cell, 7
-
M.
Ramalho-Santos,
Soonsang
Yoon,
Y.
Matsuzaki,
R.
Mulligan,
D.
Melton
(2002)
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Science, 298
-
G.
Garinis,
G.
Horst,
J.
Vijg,
J.
Hoeijmakers
(2008)
DNA damage and ageing: new-age ideas for an age-old problem
Nature Cell Biology, 10
-
Horace
Rhee,
Lisa
Polak,
E.
Fuchs
(2006)
Lhx2 Maintains Stem Cell Character in Hair Follicles
Science, 312
-
E.
Deschene,
P.
Myung,
P.
Rompolas,
Giovanni
Zito,
T.
Sun,
M.
Taketo,
I.
Saotome,
V.
Greco
(2014)
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Science, 343
-
(2006)
A role for p16? Br
-
V.
Gray-Schopfer,
S.
Cheong,
H.
Chong,
J.
Chow,
T.
Moss,
Z.
Abdel‐Malek,
R.
Marais,
D.
Wynford‐Thomas,
D.
Bennett
(2006)
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
British Journal of Cancer, 95
-
Elke
Schaffitzel,
Maren
Hertweck
(2006)
Recent aging research in Caenorhabditis elegans
Experimental Gerontology, 41
-
Chung-Shi
Wen,
Swei-Ming
Lin,
Yun
Chen,
Jin-Cherng
Chen,
Yao-Hung
Wang,
S.
Tseng
(2003)
Radiation-induced temporary alopecia after embolization of cerebral arteriovenous malformations
Clinical Neurology and Neurosurgery, 105
-
D.
Huang,
Brad
Sherman,
R.
Lempicki
(2008)
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Nature Protocols, 4
-
J.
Encinas,
T.
Michurina,
N.
Peunova,
June‐Hee
Park,
J.
Tordo,
D.
Peterson,
G.
Fishell,
A.
Koulakov,
G.
Enikolopov
(2011)
Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus.
Cell stem cell, 8 5
-
M.
Haigis,
B.
Yankner
(2010)
The aging stress response.
Molecular cell, 40 2
-
S.
Tanimura,
Y.
Tadokoro,
K.
Inomata,
N.
Binh,
W.
Nishie,
S.
Yamazaki,
H.
Nakauchi,
Y.
Tanaka,
J.
McMillan,
D.
Sawamura,
K.
Yancey,
Hiroshi
Shimizu,
E.
Nishimura
(2011)
Hair follicle stem cells provide a functional niche for melanocyte stem cells.
Cell stem cell, 8 2
-
宏之
清水
(2009)
Humanization of autoantigen: 水疱性類天疱瘡の病態解明と新規治療法開発
-
L.
Garza,
Chao-Chun
Yang,
Tailun
Zhao,
Hanz
Blatt,
Michelle
Lee,
Helen
He,
D.
Stanton,
L.
Carrasco,
J.
Spiegel,
J.
Tobias,
G.
Cotsarelis
(2011)
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.
The Journal of clinical investigation, 121 2
-
Kimi
Yamakoshi,
Akiko
Takahashi,
Fumiko
Hirota,
Rika
Nakayama,
N.
Ishimaru,
Y.
Kubo,
D.
Mann,
M.
Ohmura,
A.
Hirao,
H.
Saya,
S.
Arase,
Y.
Hayashi,
K.
Nakao,
M.
Matsumoto,
N.
Ohtani,
E.
Hara
(2009)
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
The Journal of Cell Biology, 186
-
C.
Margadant,
Rabab
Charafeddine,
A.
Sonnenberg
(2010)
Unique and redundant functions of integrins in the epidermis
The FASEB Journal, 24
-
F.
Watt,
K.
Jensen
(2009)
Epidermal stem cell diversity and quiescence
EMBO Molecular Medicine, 1
-
M.
Serrano,
M.
Blasco
(2007)
Cancer and ageing: convergent and divergent mechanisms
Nature Reviews Molecular Cell Biology, 8
-
L.
Smith
(1989)
Histopathologic characteristics and ultrastructure of aging skin.
Cutis, 43 5
-
(2014)
Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4
-
G.
Martin
(2005)
Genetic Modulation of Senescent Phenotypes in Homo sapiens
Cell, 120
-
B.
Weinert,
P.
Timiras
(2003)
Invited review: Theories of aging.
Journal of applied physiology, 95 4
-
O.
Lacharrière,
C.
Deloche,
C.
Misciali,
B.
Piraccini,
C.
Vincenzi,
P.
Bastien,
I.
Tardy,
B.
Bernard,
A.
Tosti
(2001)
Hair diameter diversity: a clinical sign reflecting the follicle miniaturization.
Archives of dermatology, 137 5
-
E.
Olasz,
J.
Roh,
C.
Yee,
K.
Arita,
M.
Akiyama,
H.
Shimizu,
J.
Vogel,
K.
Yancey
(2007)
Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice.
The Journal of investigative dermatology, 127 12
-
F.
Watt,
Soline
Estrach,
C.
Ambler
(2008)
Epidermal Notch signalling: differentiation, cancer and adhesion
Current Opinion in Cell Biology, 20
-
C.
Trempus,
R.
Morris,
C.
Bortner,
G.
Cotsarelis,
Randall
Faircloth,
J.
Reece,
R.
Tennant
(2003)
Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.
The Journal of investigative dermatology, 120 4
-
P.
Hasty,
J.
Campisi,
J.
Hoeijmakers,
H.
Steeg,
J.
Vijg
(2003)
Aging and Genome Maintenance: Lessons from the Mouse?
Science, 299
-
Peggy
Janich,
G.
Pascual,
A.
Merlos-Suárez,
E.
Batlle,
J.
Ripperger,
U.
Albrecht,
H.
Cheng,
K.
Obrietan,
L.
Croce,
S.
Benitah
(2011)
The circadian molecular clock creates epidermal stem cell heterogeneity
Nature, 480
-
Philippe
Soriano
(1999)
Generalized lacZ expression with the ROSA26 Cre reporter strain
Nature Genetics, 21
-
D.
Lombard,
Katrin
Chua,
R.
Mostoslavsky,
S.
Franco,
M.
Gostissa,
F.
Alt
(2005)
DNA Repair, Genome Stability, and Aging
Cell, 120
-
M.
Santos,
R.
Faryabi,
Aysegul
Ergen,
Amanda
Day,
Amy
Malhowski,
A.
Canela,
M.
Onozawa,
Ji-Eun
Lee,
E.
Callen,
P.
Gutierrez-Martinez,
Hua-Tang
Chen,
N.
Wong,
Nadia
Finkel,
Aniruddha
Deshpande,
S.
Sharrow,
Derrick
Rossi,
Keisuke
Ito,
K.
Ge,
P.
Aplan,
S.
Armstrong,
A.
Nussenzweig
(2014)
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier
Nature, 514
-
O.
Lacharrière,
C.
Deloche,
C.
Misciali,
B.
Piraccini,
C.
Vincenzi,
P.
Bastien,
I.
Tardy,
B.
Bernard,
A.
Tosti
(2013)
A Clinical Sign Reflecting the Follicle Miniaturization
-
C.
López-Otín,
M.
Blasco,
L.
Partridge,
M.
Serrano,
G.
Kroemer
(2013)
The Hallmarks of Aging
Cell, 153
-
J.
Hoeijmakers
(2009)
DNA damage, aging, and cancer.
The New England journal of medicine, 361 15
-
G.
Nahler
(2009)
dose response relationship
-
Rene
Adam,
Hanseul
Yang,
Shira
Rockowitz,
Samantha
Larsen,
M.
Nikolova,
D.
Oristian,
Lisa
Polak,
Meelis
Kadaja,
Amma
Asare,
D.
Zheng,
E.
Fuchs
(2015)
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
Nature, 521
-
Shoichiro
Takeishi,
Akinobu
Matsumoto,
I.
Onoyama,
K.
Naka,
A.
Hirao,
K.
Nakayama
(2013)
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Cancer cell, 23 3
-
G.
Cotsarelis
(2006)
Epithelial stem cells: a folliculocentric view.
The Journal of investigative dermatology, 126 7
-
Jianwei
Wang,
Qianmei
Sun,
Yohei
Morita,
Hong
Jiang,
Alexander
Groß,
A.
Lechel,
K.
Hildner,
Luis
Guachalla,
A.
Gompf,
D.
Hartmann,
A.
Schambach,
T.
Wüstefeld,
D.
Dauch,
H.
Schrezenmeier,
W.
Hofmann,
H.
Nakauchi,
Z.
Ju,
H.
Kestler,
L.
Zender,
K.
Rudolph
(2014)
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
-
A.
Harding
(2007)
The stem cell race
Cynthia
Fox
Cell of Cells: the Global Race to Capture and Control the Stem Cell
The Lancet, 369
-
T.
Tumbar,
Géraldine
Guasch,
V.
Greco,
C.
Blanpain,
W.
Lowry,
Michael
Rendl,
E.
Fuchs
(2004)
Defining the Epithelial Stem Cell Niche in Skin
Science, 303
-
Rogério
Castilho,
C.
Squarize,
Lewis
Chodosh,
Bart
Williams,
J.
Gutkind
(2009)
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.
Cell stem cell, 5 3
-
C.
Bonnart,
C.
Deraison,
M.
Lacroix,
Y.
Uchida,
C.
Besson,
A.
Robin,
A.
Briot,
M.
Gonthier,
L.
Lamant,
P.
Dubus,
B.
Monsarrat,
A.
Hovnanian
(2010)
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
The Journal of clinical investigation, 120 3
-
Brice
Keyes,
J.
Segal,
Evan
Heller,
Wen-Hui
Lien,
Chiung-Ying
Chang,
Xingyi
Guo,
D.
Oristian,
D.
Zheng,
E.
Fuchs
(2013)
Nfatc1 orchestrates aging in hair follicle stem cells
Proceedings of the National Academy of Sciences, 110
-
Jan
Boer,
J.
Wit,
H.
Steeg,
Rob
Berg,
Hans
Morreau,
Pim
Visser,
Alan
Lehmann,
Marinus
Duran,
J.
Hoeijmakers,
G.
Weeda
(1998)
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Molecular cell, 1 7
-
R.
Bertell
(1977)
X‐ray exposure and premature aging
Journal of Surgical Oncology, 9
-
A.
Kligman
(1988)
The comparative histopathology of male-pattern baldness and senescent baldness.
Clinics in dermatology, 6 4
-
G.
Moment,
A.
Woodhead,
A.
Blackett,
A.
Hollaender
(1986)
The Molecular Biology of Aging
BioScience
-
E.
Fuchs
(2009)
The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race
Cell, 137
-
K.
Inomata,
Takahiro
Aoto,
N.
Binh,
Natsuko
Okamoto,
S.
Tanimura,
T.
Wakayama,
S.
Iseki,
E.
Hara,
T.
Masunaga,
Hiroshi
Shimizu,
E.
Nishimura
(2009)
Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
Cell, 137
-
D.
Baker,
Tobias
Wijshake,
T.
Tchkonia,
N.
LeBrasseur,
Bennett
Childs,
B.
Sluis,
J.
Kirkland,
J.
Deursen
(2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Nature, 479
-
F.
Johnson,
D.
Sinclair,
L.
Guarente
(1999)
Molecular Biology of Aging
Cell, 96
-
Lan
Lin,
T.
Betsuyaku,
Lisa
Heimbach,
Ning
Li,
D.
Rubenstein,
S.
Shapiro,
L.
An,
G.
Giudice,
L.
Diaz,
R.
Senior,
Zhi
Liu
(2012)
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Matrix biology : journal of the International Society for Matrix Biology, 31 1
-
R.
Morris,
Yaping
Liu,
L.
Marles,
Zaixin
Yang,
C.
Trempus,
Shulan
Li,
Jamie
Lin,
J.
Sawicki,
G.
Cotsarelis
(2004)
Capturing and profiling adult hair follicle stem cells
Nature Biotechnology, 22
-
C.
Blanpain,
W.
Lowry,
H.
Pasolli,
E.
Fuchs
(2006)
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Genes & development, 20 21
-
S.
Laval,
Hanane
Laklai,
Marjorie
Fanjul,
Mélanie
Pucelle,
Henrik
Laurell,
A.
Billon-Galés,
S.
Guellec,
Marie-Bernadette
Delisle,
A.
Sonnenberg,
C.
Susini,
S.
Pyronnet,
Corinne
Bousquet
(2014)
Dual roles of hemidesmosomal proteins in the pancreatic epithelium: the phosphoinositide 3-kinase decides
Oncogene, 33
-
Derrick
Rossi,
D.
Bryder,
J.
Seita,
A.
Nussenzweig,
J.
Hoeijmakers,
I.
Weissman
(2007)
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Nature, 447
-
(2002)
Public or private? Nat
-
B.
Lawenda,
H.
Gagne,
D.
Gierga,
A.
Niemierko,
W.
Wong,
N.
Tarbell,
George
Chen,
F.
Hochberg,
J.
Loeffler
(2004)
Permanent alopecia after cranial irradiation: dose-response relationship.
International journal of radiation oncology, biology, physics, 60 3
-
H.
Pasolli,
Alicia
Folgueras,
E.
Fuchs
(2014)
Architectural Niche Organization by LHX2 is Linked to Hair Follicle Stem Cell Function
Microscopy and Microanalysis, 20
