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Identification and Characterization of MicroRNAs Expressed in the Mouse Eye

Identification and Characterization of MicroRNAs Expressed in the Mouse Eye Identification and Characterization of MicroRNAs Expressed in the Mouse Eye 1 1 1,2 1 Marianthi Karali, Ivana Peluso, Valeria Marigo, and Sandro Banfi PURPOSE. MicroRNAs (miRNAs) are a class of small, endogenous target sites in the 3 untranslated region (UTR) of messenger 1,2 RNAs that negatively regulate gene expression post-transcrip- RNAs leading to a reduction of translational efficiency. Cur- tionally by binding to target sites in the 3 untranslated region rently, over 300 miRNAs (miRNA registry, http://microrna (UTR) of messenger RNAs. Although they have been found to .sanger.ac.uk/sequences/ provided in the public domain by the regulate developmental and physiological processes in several Sanger Centre, Hinxton, UK) have been identified in the hu- organs and tissues, their role in the eye transcriptome is com- man and mouse genomes, but estimates suggest that their pletely unknown. This study was conducted to gain under- actual number may be close to 1000. As each miRNA can standing of their eye-related function in mammals, by looking regulate, on average, the expression of approximately 100 to 5,6 for miRNAs significantly expressed in the mouse eye by means 200 target genes, the miRNA apparatus seems to participate of high-resolution expression analysis. in the control of gene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Investigative Ophthalmology & Visual Science Unpaywall

Identification and Characterization of MicroRNAs Expressed in the Mouse Eye

Karali, Marianthi; Peluso, Ivana; Marigo, Valeria; Banfi, Sandro
Investigative Ophthalmology & Visual Science – Jan 25, 2007
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Publisher
Unpaywall
ISSN
0146-0404
DOI
10.1167/iovs.06-0866
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Abstract

Identification and Characterization of MicroRNAs Expressed in the Mouse Eye 1 1 1,2 1 Marianthi Karali, Ivana Peluso, Valeria Marigo, and Sandro Banfi PURPOSE. MicroRNAs (miRNAs) are a class of small, endogenous target sites in the 3 untranslated region (UTR) of messenger 1,2 RNAs that negatively regulate gene expression post-transcrip- RNAs leading to a reduction of translational efficiency. Cur- tionally by binding to target sites in the 3 untranslated region rently, over 300 miRNAs (miRNA registry, http://microrna (UTR) of messenger RNAs. Although they have been found to .sanger.ac.uk/sequences/ provided in the public domain by the regulate developmental and physiological processes in several Sanger Centre, Hinxton, UK) have been identified in the hu- organs and tissues, their role in the eye transcriptome is com- man and mouse genomes, but estimates suggest that their pletely unknown. This study was conducted to gain under- actual number may be close to 1000. As each miRNA can standing of their eye-related function in mammals, by looking regulate, on average, the expression of approximately 100 to 5,6 for miRNAs significantly expressed in the mouse eye by means 200 target genes, the miRNA apparatus seems to participate of high-resolution expression analysis. in the control of gene

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Investigative Ophthalmology & Visual Science – Unpaywall

Published: Jan 25, 2007

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