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Patterns of treatment response in newly diagnosed epilepsy

Patterns of treatment response in newly diagnosed epilepsy ARTICLES Patterns of treatment response in newly diagnosed epilepsy M.J. Brodie, MD ABSTRACT S.J.E. Barry, PhD Objective: To delineate the temporal patterns of outcome and to determine the probability of G.A. Bamagous, PhD seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy. J.D. Norrie, MSc Methods: Patients in whom epilepsy was diagnosed and the first antiepileptic drug prescribed P. Kwan, MD, PhD between July 1, 1982, and April 1, 2006, were followed up until March 31, 2008. Outcomes were categorized into 4 patterns: A) early and sustained seizure freedom; B) delayed but sus- tained seizure freedom; C) fluctuation between periods of seizure freedom and relapse; and D) Correspondence & reprint seizure freedom never attained. Probability of seizure freedom with successive drug regimens requests to Dr. Kwan: [email protected] was compared. Seizure freedom was defined as no seizures for 1 year. Results: A total of 1,098 patients were included (median age 32 years, range 9–93). At the last clinic visit, 749 (68%) patients were seizure-free, 678 (62%) on monotherapy. Outcome pattern A was observed in 408 (37%), pattern B in 246 (22%), pattern C in 172 (16%), and pattern D in 272 (25%) patients. There was a higher probability http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurology Wolters Kluwer Health

Patterns of treatment response in newly diagnosed epilepsy

Kwan, P.
Neurology , Volume 78 (20) – May 1, 2012
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Copyright
Copyright © 2012 by AAN Enterprises, Inc.
ISSN
0028-3878
eISSN
1526-632X
DOI
10.1212/WNL.0b013e3182563b19
pmid
22573629
Publisher site
See Article on Publisher Site

Abstract

ARTICLES Patterns of treatment response in newly diagnosed epilepsy M.J. Brodie, MD ABSTRACT S.J.E. Barry, PhD Objective: To delineate the temporal patterns of outcome and to determine the probability of G.A. Bamagous, PhD seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy. J.D. Norrie, MSc Methods: Patients in whom epilepsy was diagnosed and the first antiepileptic drug prescribed P. Kwan, MD, PhD between July 1, 1982, and April 1, 2006, were followed up until March 31, 2008. Outcomes were categorized into 4 patterns: A) early and sustained seizure freedom; B) delayed but sus- tained seizure freedom; C) fluctuation between periods of seizure freedom and relapse; and D) Correspondence & reprint seizure freedom never attained. Probability of seizure freedom with successive drug regimens requests to Dr. Kwan: [email protected] was compared. Seizure freedom was defined as no seizures for 1 year. Results: A total of 1,098 patients were included (median age 32 years, range 9–93). At the last clinic visit, 749 (68%) patients were seizure-free, 678 (62%) on monotherapy. Outcome pattern A was observed in 408 (37%), pattern B in 246 (22%), pattern C in 172 (16%), and pattern D in 272 (25%) patients. There was a higher probability

Journal

Neurology – Wolters Kluwer Health

Published: May 1, 2012

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