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Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults The Cardiovascular Health Study

Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial... Arrhythmia/Electrophysiology Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults The Cardiovascular Health Study Jason H.Y. Wu, PhD; Rozenn N. Lemaitre, PhD, MPH; Irena B. King, PhD; Xiaoling Song, PhD; Frank M. Sacks, MD; Eric B. Rimm, ScD; Susan R. Heckbert, MD, PhD; David S. Siscovick, MD, MPH; Dariush Mozaffarian, MD, DrPH Background—Experimental studies suggest that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) may reduce the risk of atrial fibrillation (AF). Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure. Methods and Results—Among 3326 US men and women 65 years of age and free of AF or heart failure at baseline, plasma phospholipid levels of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were measured at baseline by use of standardized methods. Incident AF (789 cases) was identified prospectively from hospital discharge records and study visit ECGs during 31 169 person-years of follow-up (1992–2006). In multivariable Cox models adjusted for other risk factors, the relative risk in the top versus lowest quartile of total n-3 PUFAs (eicosapentaenoic aciddocosapentaenoic aciddocosahexaenoic acid) levels was 0.71 (95% confidence http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults The Cardiovascular Health Study

Mozaffarian, Dariush
Circulation , Volume 125 (9) – Mar 1, 2012
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Copyright
© 2012 American Heart Association, Inc.
ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/CIRCULATIONAHA.111.062653
pmid
22282329
Publisher site
See Article on Publisher Site

Abstract

Arrhythmia/Electrophysiology Association of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids With Incident Atrial Fibrillation in Older Adults The Cardiovascular Health Study Jason H.Y. Wu, PhD; Rozenn N. Lemaitre, PhD, MPH; Irena B. King, PhD; Xiaoling Song, PhD; Frank M. Sacks, MD; Eric B. Rimm, ScD; Susan R. Heckbert, MD, PhD; David S. Siscovick, MD, MPH; Dariush Mozaffarian, MD, DrPH Background—Experimental studies suggest that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) may reduce the risk of atrial fibrillation (AF). Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure. Methods and Results—Among 3326 US men and women 65 years of age and free of AF or heart failure at baseline, plasma phospholipid levels of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were measured at baseline by use of standardized methods. Incident AF (789 cases) was identified prospectively from hospital discharge records and study visit ECGs during 31 169 person-years of follow-up (1992–2006). In multivariable Cox models adjusted for other risk factors, the relative risk in the top versus lowest quartile of total n-3 PUFAs (eicosapentaenoic aciddocosapentaenoic aciddocosahexaenoic acid) levels was 0.71 (95% confidence

Journal

Circulation – Wolters Kluwer Health

Published: Mar 1, 2012

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