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Immunohistological localization of human pregnancy-associated endometrial α2-globulin (α2-PEG), a glycosylated β-lactoglobulin homologue, in the decidua and placenta during pregnancy

Immunohistological localization of human pregnancy-associated endometrial α2-globulin (α2-PEG), a... Summary. Monoclonal and polyclonal antibodies to pregnancy-associated endometrial α2-globulin (α2-PEG), a glycosylated human β-lactoglobulin homologue, were used in an immunohistological technique to determine the cellular localization of this protein in the decidua and placental tissues during pregnancy. During the first trimester the protein was principally localized to the glandular epithelium of the decidua spongiosa region of the endometrium with only weak staining associated with glands of the decidualized decidua compacta region. No significant cellular staining was detected in the decidua capsularis. At term in the decidua of the amniochorion and the placental bed weak staining for α2-PEG was only associated with the epithelium of attenuated glands. No significant staining was detected in the placenta during pregnancy. These results suggest that the epithelium of glands associated with non-decidualized stroma represents the primary source of α2-PEG during the first trimester and that a function of the decidua spongiosa in early pregnancy may be related to production of α2-PEG. The decline in production of α2-PEG during pregnancy is suggested to result from involution of the decidua spongiosa and at term the attenuated glands of the decidua represents the source of α2-PEG.Keywords: endometrium; decidua; placenta; pregnancy-associated proteins; β-lactoglobulin homologue; man http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reproduction Bioscientifica

Immunohistological localization of human pregnancy-associated endometrial α2-globulin (α2-PEG), a glycosylated β-lactoglobulin homologue, in the decidua and placenta during pregnancy

Waites, Gillian T.; Bell, S. C.
Reproduction , Volume 87 (1) – Sep 1, 1989
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Publisher
Bioscientifica
Copyright
Copyright © 1989 The Authors. All Rights Reserved.
ISSN
1470-1626
eISSN
1741-7899
DOI
10.1530/jrf.0.0870291
Publisher site
See Article on Publisher Site

Abstract

Summary. Monoclonal and polyclonal antibodies to pregnancy-associated endometrial α2-globulin (α2-PEG), a glycosylated human β-lactoglobulin homologue, were used in an immunohistological technique to determine the cellular localization of this protein in the decidua and placental tissues during pregnancy. During the first trimester the protein was principally localized to the glandular epithelium of the decidua spongiosa region of the endometrium with only weak staining associated with glands of the decidualized decidua compacta region. No significant cellular staining was detected in the decidua capsularis. At term in the decidua of the amniochorion and the placental bed weak staining for α2-PEG was only associated with the epithelium of attenuated glands. No significant staining was detected in the placenta during pregnancy. These results suggest that the epithelium of glands associated with non-decidualized stroma represents the primary source of α2-PEG during the first trimester and that a function of the decidua spongiosa in early pregnancy may be related to production of α2-PEG. The decline in production of α2-PEG during pregnancy is suggested to result from involution of the decidua spongiosa and at term the attenuated glands of the decidua represents the source of α2-PEG.Keywords: endometrium; decidua; placenta; pregnancy-associated proteins; β-lactoglobulin homologue; man

Journal

Reproduction – Bioscientifica

Published: Sep 1, 1989

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