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Association of FKBP5Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

Association of FKBP5Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder... ORIGINAL CONTRIBUTION Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults Elisabeth B. Binder, MD, PhD Context In addition to trauma exposure, other factors contribute to risk for devel- Rebekah G. Bradley, PhD opment of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and envi- ronmental factors are contributory, with child abuse providing significant risk liability. Wei Liu, PhD Objective To increase understanding of genetic and environmental risk factors as Michael P. Epstein, PhD well as their interaction in the development of PTSD by gene  environment interac- Todd C. Deveau, BS tions of child abuse, level of non–child abuse trauma exposure, and genetic polymor- phisms at the stress-related gene FKBP5. Kristina B. Mercer, MPH Design, Setting, and Participants A cross-sectional study examining genetic and Yilang Tang, MD, PhD psychological risk factors in 900 nonpsychiatric clinic patients (762 included for all geno- Charles F. Gillespie, MD, PhD type studies) with significant levels of childhood abuse as well as non–child abuse trauma Christine M. Heim, PhD using a verbally presented survey combined with single-nucleotide polymorphism (SNP) genotyping. Participants were primarily urban, low-income, black (95%) men and Charles B. Nemeroff, MD, PhD women seeking http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association of FKBP5Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

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References (101)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.11.1291
pmid
18349090
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults Elisabeth B. Binder, MD, PhD Context In addition to trauma exposure, other factors contribute to risk for devel- Rebekah G. Bradley, PhD opment of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and envi- ronmental factors are contributory, with child abuse providing significant risk liability. Wei Liu, PhD Objective To increase understanding of genetic and environmental risk factors as Michael P. Epstein, PhD well as their interaction in the development of PTSD by gene  environment interac- Todd C. Deveau, BS tions of child abuse, level of non–child abuse trauma exposure, and genetic polymor- phisms at the stress-related gene FKBP5. Kristina B. Mercer, MPH Design, Setting, and Participants A cross-sectional study examining genetic and Yilang Tang, MD, PhD psychological risk factors in 900 nonpsychiatric clinic patients (762 included for all geno- Charles F. Gillespie, MD, PhD type studies) with significant levels of childhood abuse as well as non–child abuse trauma Christine M. Heim, PhD using a verbally presented survey combined with single-nucleotide polymorphism (SNP) genotyping. Participants were primarily urban, low-income, black (95%) men and Charles B. Nemeroff, MD, PhD women seeking

Journal

JAMA – American Medical Association

Published: Mar 19, 2008

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