Access the full text.
Sign up today, get DeepDyve free for 14 days.
Wenxue Li, Neva West, E. Colla, O. Pletnikova, J. Troncoso, L. Marsh, T. Dawson, P. Jäkälä, T. Hartmann, D. Price, Michael Lee (2005)
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.Proceedings of the National Academy of Sciences of the United States of America, 102 6
J. Duda, Benoit Giasson, T. Gur, T. Montine, D. Robertson, I. Biaggioni, H. Hurtig, M. Stern, S. Gollomp, M. Grossman, V. Lee, J. Trojanowski (2000)
Immunohistochemical and Biochemical Studies Demonstrate a Distinct Profile of α‐Synuclein Permutations in Multiple System AtrophyJNEN: Journal of Neuropathology & Experimental Neurology, 59
Hogyu Han, P. Weinreb, P. Lansbury (1995)
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?Chemistry & biology, 2 3
Clavaguera (2009)
Transmission and spreading of tauopathy in transgenic mouse brainNat. Cell Biol., 11
H. Braak, K. Tredici, U. Rüb, R. Vos, Ernst Steur, E. Braak (2003)
Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 24
L. Serpell, J. Berriman, R. Jakes, M. Goedert, R. Crowther (2000)
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation.Proceedings of the National Academy of Sciences of the United States of America, 97 9
Jeffrey Kessler, J. Rochet, P. Lansbury (2003)
The N-Terminal Repeat Domain of α-Synuclein Inhibits β-Sheet and Amyloid Fibril Formation†Biochemistry, 42
Paula Desplats, He‐Jin Lee, Eun-Jin Bae, C. Patrick, E. Rockenstein, L. Crews, B. Spencer, E. Masliah, Seung-Jae Lee (2009)
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synucleinProceedings of the National Academy of Sciences, 106
Hideo Fujiwara, M. Hasegawa, N. Dohmae, A. Kawashima, E. Masliah, M. Goldberg, Jie Shen, K. Takio, T. Iwatsubo (2002)
α-Synuclein is phosphorylated in synucleinopathy lesionsNature Cell Biology, 4
B. Winner, R. Jappelli, S. Maji, Paula Desplats, Leah Boyer, S. Aigner, C. Hetzer, Thomas Loher, M. Vilar, S. Campioni, Christos Tzitzilonis, A. Soragni, S. Jessberger, H. Mira, A. Consiglio, E. Pham, E. Masliah, F. Gage, R. Riek (2011)
In vivo demonstration that α-synuclein oligomers are toxicProceedings of the National Academy of Sciences, 108
William Banks, V. Akerstrom, A. Kastin (1998)
Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor.Journal of cell science, 111 ( Pt 4)
C. Hansen, E. Angot, A. Bergström, Jennifer Steiner, Laura Pieri, G. Paul, T. Outeiro, R. Melki, P. Kallunki, Karina Fog, Jia-Yi Li, P. Brundin (2011)
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.The Journal of clinical investigation, 121 2
I. Breskin, J. Soriano, E. Moses, Tsvi Tlusty (2006)
Percolation in living neural networks.Physical review letters, 97 18
S. Chandra, G. Gallardo, R. Fernández-Chacón, O. Schlüter, T. Südhof (2005)
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.Cell, 123 3
M. Baba, S. Nakajo, Ping-hui Tu, T. Tomita, K. Nakaya, V. Lee, J. Trojanowski, T. Iwatsubo (1998)
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.The American journal of pathology, 152 4
A. Abeliovich, Y. Schmitz, I. Fariñas, D. Choi-Lundberg, W. Ho, P. Castillo, N. Shinsky, J. Verdugo, M. Armanini, A. Ryan, M. Hynes, H. Phillips, D. Sulzer, A. Rosenthal (2000)
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine SystemNeuron, 25
J. Kordower, Y. Chu, R. Hauser, T. Freeman, W. Olanow (2008)
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's diseaseNature Medicine, 14
I. Murray, B. Giasson, Shawn Quinn, V. Koppaka, P. Axelsen, H. Ischiropoulos, J. Trojanowski, V. Lee (2003)
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.Biochemistry, 42 28
E. Waxman, B. Giasson (2008)
Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of &agr;-SynucleinJournal of Neuropathology and Experimental Neurology, 67
Hideo Fujiwara, M. Hasegawa, N. Dohmae, A. Kawashima, E. Masliah, M. Goldberg, Jie Shen, K. Takio, T. Iwatsubo (2002)
alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature cell biology, 4 2
(2011)
Neuron Neuron Dysfunction in Model of a-syn Transmission Neuron
A. Aguzzi, L. Rajendran (2009)
The Transcellular Spread of Cytosolic Amyloids, Prions, and PrionoidsNeuron, 64
A. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, R. Nussbaum, S. Lincoln, A. Crawley, M. Hanson, D. Maraganore, C. Adler, Michael Cookson, M. Muenter, M. Baptista, D. Miller, J. Blancato, J. Hardy, K. Gwinn‐Hardy (2003)
α-Synuclein Locus Triplication Causes Parkinson's DiseaseScience, 302
M. Spillantini, R. Crowther, R. Jakes, N. Cairns, P. Lantos, M. Goedert (1998)
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, 251 3
H. Braak, E. Braak (2004)
Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 82
Bess Frost, R. Jacks, M. Diamond (2009)
Propagation of Tau Misfolding from the Outside to the Inside of a Cell*Journal of Biological Chemistry, 284
Deepak Sampathu, B. Giasson, A. Pawlyk, J. Trojanowski, V. Lee (2003)
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.The American journal of pathology, 163 1
J. Soriano, M. Martínez, Tsvi Tlusty, E. Moses (2008)
Development of input connections in neural culturesProceedings of the National Academy of Sciences, 105
Fortin (2010)
The behavior of alpha-synuclein in neuronsMov. Disord., 25
Y. Chu, J. Kordower (2007)
Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Neurobiology of Disease, 25
Stephen Wood, J. Wypych, S. Steavenson, J. Louis, M. Citron, A. Biere (1999)
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.The Journal of biological chemistry, 274 28
Jeffrey Kessler, J. Rochet, P. Lansbury (2003)
The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation.Biochemistry, 42 3
N. Gonatas, S. Avrameas (1973)
DETECTION OF PLASMA MEMBRANE CARBOHYDRATES WITH LECTIN PEROXIDASE CONJUGATESThe Journal of Cell Biology, 59
J. Touchman, A. Dehejia, O. Chiba-Falek, D. Cabin, Jody Schwartz, B. Orrison, M. Polymeropoulos, Robert Nussbaum (2001)
Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.Genome research, 11 1
E. Waxman, B. Giasson (2009)
Molecular mechanisms of alpha-synuclein neurodegeneration.Biochimica et biophysica acta, 1792 7
J. Kordower, Y. Chu, R. Hauser, C. Olanow, Thomas Freeman (2008)
Transplanted dopaminergic neurons develop PD pathologic changes: A second case reportMovement Disorders, 23
F. Clavaguera, T. Bolmont, R. Crowther, D. Abramowski, S. Frank, A. Probst, G. Fraser, A. Stalder, M. Beibel, M. Staufenbiel, M. Jucker, M. Goedert, M. Tolnay (2009)
Transmission and spreading of tauopathy in transgenic mouse brainNature cell biology, 11
D. Murphy, S. Rueter, J. Trojanowski, V. Lee (2000)
Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal NeuronsThe Journal of Neuroscience, 20
A. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, R. Nussbaum, S. Lincoln, A. Crawley, M. Hanson, D. Maraganore, C. Adler, M. Cookson, M. Muenter, M. Baptista, D. Miller, J. Blancato, J. Hardy, K. Gwinn‐Hardy (2003)
alpha-Synuclein locus triplication causes Parkinson's disease.Science, 302 5646
S. Chandra, G. Gallardo, R. Fernández-Chacón, O. Schlüter, T. Südhof (2005)
α-Synuclein Cooperates with CSPα in Preventing NeurodegenerationCell, 123
V. Uversky, Jie Li, A. Fink (2001)
Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation*The Journal of Biological Chemistry, 276
I. Murray, B. Giasson, Shawn Quinn, V. Koppaka, P. Axelsen, H. Ischiropoulos, ‡⊥ Trojanowski, V. Lee (2003)
Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro†Biochemistry, 42
A. Taylor, M. Blurton-Jones, S. Rhee, D. Cribbs, C. Cotman, N. Jeon (2005)
A microfluidic culture platform for CNS axonal injury, regeneration and transportNature Methods, 2
M. Spillantini, R. Crowther, R. Jakes, N. Cairns, P. Lantos, M. Goedert (1998)
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodiesNeuroscience Letters, 251
Jia-Yi Li, E. Englund, J. Holton, D. Soulet, P. Hagell, A. Lees, T. Lashley, N. Quinn, S. Rehncrona, A. Björklund, H. Widner, T. Révész, O. Lindvall, P. Brundin (2008)
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagationNature Medicine, 14
A. Abeliovich, Y. Schmitz, I. Fariñas, D. Choi-Lundberg, W. Ho, P. Castillo, N. Shinsky, J. Verdugo, M. Armanini, A. Ryan, M. Hynes, H. Phillips, D. Sulzer, A. Rosenthal (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.Neuron, 25 1
Eddie Lee, and Jing Guo are thanked for reading the manuscript and for helpful discussions Christina Haas, and Jeffrey Yeh for technical assistance
V. Nemani, Wei Lu, V. Berge, Ken Nakamura, Bibiana Onoa, Michael Lee, F. Chaudhry, R. Nicoll, Robert Edwards (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after EndocytosisNeuron, 65
Becket Greten-Harrison, M. Polydoro, Megumi Morimoto-Tomita, L. Diao, Andrew Williams, Esther Nie, S. Makani, Ning Tian, P. Castillo, V. Buchman, S. Chandra (2010)
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionProceedings of the National Academy of Sciences, 107
Benoit Giasson, R. Jakes, M. Goedert, J. Duda, S. Leight, J. Trojanowski, V. Lee (2000)
A panel of epitope‐specific antibodies detects protein domains distributed throughout human α‐synuclein in lewy bodies of Parkinson's diseaseJournal of Neuroscience Research, 59
R. Broadwell, B. Balin, M. Salcman (1988)
Transcytotic pathway for blood-borne protein through the blood-brain barrier.Proceedings of the National Academy of Sciences of the United States of America, 85 2
Deepak Sampathu, B. Giasson, A. Pawlyk, J. Trojanowski, V. Lee (2003)
Ubiquitination of α-Synuclein Is Not Required for Formation of Pathological Inclusions in α-SynucleinopathiesAmerican Journal of Pathology, 163
Jing Guo, V. Lee (2011)
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles*The Journal of Biological Chemistry, 286
Jacqueline Burré, Manu Sharma, Theodoros Tsetsenis, V. Buchman, M. Etherton, T. Südhof (2010)
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in VitroScience, 329
K. Conway, Seung Lee, J. Rochet, T. Ding, Robin Williamson, P. Lansbury (2000)
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.Proceedings of the National Academy of Sciences of the United States of America, 97 2
Kelvin Luk, Cheng Song, Patrick O’Brien, Anna Stieber, Jonathan Branch, K. Brunden, J. Trojanowski, V. Lee (2009)
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cellsProceedings of the National Academy of Sciences, 106
B. Giasson, I. Murray, J. Trojanowski, V. Lee (2001)
A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly*The Journal of Biological Chemistry, 276
Neuron – Unpaywall
Published: Oct 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.