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1 - Benzylimidazole inhibits thromboxane synthesis in experimental cerebral ischemia
- Publisher
- Wiley
- Copyright
- Copyright © 1987 American Neurological Association
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- DOI
- 10.1002/ana.410210209
- pmid
- 3827225
- Publisher site
- See Article on Publisher Site
Abstract
Dihydropyridine calcium channel blockers may be effective treatment for acute cerebral ischemia, but the uptake of these drugs into the brain is unknown. A 0.2‐ml bolus of (14C)nicardipine hydrochloride and (3H) water was injected into the common carotid arteries of 7 normal and 7 ischemic rats. The corrected first‐pass extraction of nicardipine, compared to water, was calculated to be 30.7% into the hemispheres and 42.3% into the hippocampi. The uptake was greater into the ischemic hemispheres (p ≤ 0.001). These data suggest that dihydropyridines are available to binding sites and calcium channels in neurons.
Journal
Annals of Neurology – Wiley
Published: Feb 1, 1987