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Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB‐1 and PABP

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP... A significant fraction of mRNAs is known to be associated in the form of mRNPs with microtubules for active transport. However, little is known about the interaction between mRNPs and microtubules and most of previous works were focused on molecular motor:microtubule interactions. Here, we have identified, via high resolution atomic force microscopy imaging, a significant binding of mRNA to microtubules mediated by two major mRNP proteins, YB‐1 and PABP. This interaction with microtubules could be of critical importance for active mRNP traffic and for mRNP granule formation. A similar role may be fulfilled by other cationic mRNA partners. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Febs Letters Wiley

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB‐1 and PABP

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References (28)

Publisher
Wiley
Copyright
© 2015 Federation of European Biochemical Societies
eISSN
1873-3468
DOI
10.1016/j.febslet.2008.07.019
Publisher site
See Article on Publisher Site

Abstract

A significant fraction of mRNAs is known to be associated in the form of mRNPs with microtubules for active transport. However, little is known about the interaction between mRNPs and microtubules and most of previous works were focused on molecular motor:microtubule interactions. Here, we have identified, via high resolution atomic force microscopy imaging, a significant binding of mRNA to microtubules mediated by two major mRNP proteins, YB‐1 and PABP. This interaction with microtubules could be of critical importance for active mRNP traffic and for mRNP granule formation. A similar role may be fulfilled by other cationic mRNA partners.

Journal

Febs LettersWiley

Published: Aug 20, 2008

Keywords: ; ; ; ; ;

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