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Y. González-Lama, F. Bermejo, A. López-Sanromán, V. García‐Sánchez, M. Esteve, J. Cabriada, A. McNicholl, R. Pajares, F. Casellas, O. Merino, D. Carpio, M. Vera, C. Muñoz, Miguel Rebollar, L. Benito, L. Bujanda, F. García-Fernandez, E. Ricart, D. Ginard, M. Velasco, J. Carneros, N. Manceñido, M. Calvo, A. Algaba, C. Froilán, C. Cara, J. Mate, L. Abreu, J. Gisbert (2011)
Thiopurine methyl‐transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine‐treated inflammatory bowel disease patientsAlimentary Pharmacology & Therapeutics, 34
M. Relling, T. Klein (2011)
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research NetworkClinical Pharmacology & Therapeutics, 89
E. Krynetski, W. Evans (2003)
Drug methylation in cancer therapy: lessons from the TPMT polymorphismOncogene, 22
M. Relling, Eric Gardner, W. Sandborn, Kjeld Schmiegelow, Pui Ch, S. Yee, C. Stein, M. Carrillo, William Evans, Teri Klein (2011)
Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine DosingClinical Pharmacology & Therapeutics, 89
T. Beaumais, M. Fakhoury, Y. Médard, Said Azougagh, Daolun Zhang, K. Yakouben, É. Jacqz-Aigrain (2011)
Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.British journal of clinical pharmacology, 71 4
The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Methyltransferase Genotype and Thiopurine Dosing was originally published in March 2011. We reviewed recent literature and concluded that although relevant new evidence has been generated, none of the evidence would change the primary dosing recommendations in the original guideline; therefore, the original publication remains clinically current. Up‐to‐date information on thiopurine methyltransferase (TPMT) gene alleles and nomenclature can be found at PharmGKB (http://www.pharmgkb.org).
Clinical Pharmacology & Therapeutics – Wiley
Published: Apr 1, 2013
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