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Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis

Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis Christian A. Gleissner, Norbert Leitinger, Klaus Ley therosclerosis is a chronic inflammatory disease of the these adhesion molecules, chemokines play an important role 1–3 19 Aarterial wall with enormous epidemiological rele- in monocyte recruitment. The mechanisms of monocyte 4,5 14,16 vance. Recruitment of monocytes to the vascular wall is a recruitment to the vessel wall have been reviewed. key feature in the pathogeneses of atherosclerotic lesions. Through a complex cascade of interactions between adhesion Native and Modified Forms of LDL molecules and chemotactic factors, monocytes enter the LDL is a heterogeneous class of lipoprotein particles consist- ing of a hydrophobic core containing triglycerides and cho- subendothelial space, where they develop into macrophages, lesterol esters in a hydrophilic shell of phospholipids, free foam cells, and dendritic cells under the influence of cyto- 6–8 kines, growth factors, and lipoproteins. Foam cells even- cholesterol, and apolipoproteins (predominantly B-100), the latter acting as ligands for lipoprotein receptors. The density tually undergo secondary necrosis and form the lipid core of of LDL ranges from 1.019 to 1.063 g/mL, its diameter is advanced atherosclerotic plaques. When exposed by rupture or erosion, it triggers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hypertension Wolters Kluwer Health

Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis

Ley, Klaus
Hypertension , Volume 50 (2) – Aug 1, 2007
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ISSN
0194-911X
eISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.107.089854
pmid
17548720
Publisher site
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Abstract

Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis Christian A. Gleissner, Norbert Leitinger, Klaus Ley therosclerosis is a chronic inflammatory disease of the these adhesion molecules, chemokines play an important role 1–3 19 Aarterial wall with enormous epidemiological rele- in monocyte recruitment. The mechanisms of monocyte 4,5 14,16 vance. Recruitment of monocytes to the vascular wall is a recruitment to the vessel wall have been reviewed. key feature in the pathogeneses of atherosclerotic lesions. Through a complex cascade of interactions between adhesion Native and Modified Forms of LDL molecules and chemotactic factors, monocytes enter the LDL is a heterogeneous class of lipoprotein particles consist- ing of a hydrophobic core containing triglycerides and cho- subendothelial space, where they develop into macrophages, lesterol esters in a hydrophilic shell of phospholipids, free foam cells, and dendritic cells under the influence of cyto- 6–8 kines, growth factors, and lipoproteins. Foam cells even- cholesterol, and apolipoproteins (predominantly B-100), the latter acting as ligands for lipoprotein receptors. The density tually undergo secondary necrosis and form the lipid core of of LDL ranges from 1.019 to 1.063 g/mL, its diameter is advanced atherosclerotic plaques. When exposed by rupture or erosion, it triggers

Journal

Hypertension – Wolters Kluwer Health

Published: Aug 1, 2007

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