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Intraoperative smear cytology of meningeal melanocytoma of the posterior fossa

Intraoperative smear cytology of meningeal melanocytoma of the posterior fossa Introduction Primary pigmented lesions of the central nervous system (CNS) are uncommon and range from melanosis of the leptomeninges to malignant melanoma. Meningeal melanocytomas lie within the well‐differentiated end of this spectrum. The tumours arising in the posterior fossa may mimic acoustic neuromas or meningiomas as far as the location and radiological appearance is considered. The diagnosis is made intraoperatively based on the gross and cytological appearance of the neoplasm. The cytological features of this lesion have been rarely highlighted in the literature. We present a case of meningeal melanocytoma of the posterior fossa. Case report A 35‐year‐old male was admitted with complaints of generalized weakness, fever and altered sensorium of 4 days duration. He had a history of recurrent headaches and vomiting for 2 months. A computed tomography scan showed a right cerebello‐pontine angle lesion. At posterior fossa craniotomy, a dark brown to black, soft, dural‐based tumour, located at the right cerebello‐pontine angle was excised. The peri‐operative diagnoses considered were melanotic schwannoma and malignant melanoma. The specimen was sent in saline for intraoperative consultation. The smears prepared were fixed in 95% alcohol and stained with haematoxylin and eosin. On cytological evaluation the smears, were cellular and made http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytopathology Wiley

Intraoperative smear cytology of meningeal melanocytoma of the posterior fossa

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References (21)

Publisher
Wiley
Copyright
© 2007 The Authors. Journal compilation © 2007 Blackwell Publishing Ltd
ISSN
0956-5507
eISSN
1365-2303
DOI
10.1111/j.1365-2303.2007.00536.x
pmid
18093219
Publisher site
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Abstract

Introduction Primary pigmented lesions of the central nervous system (CNS) are uncommon and range from melanosis of the leptomeninges to malignant melanoma. Meningeal melanocytomas lie within the well‐differentiated end of this spectrum. The tumours arising in the posterior fossa may mimic acoustic neuromas or meningiomas as far as the location and radiological appearance is considered. The diagnosis is made intraoperatively based on the gross and cytological appearance of the neoplasm. The cytological features of this lesion have been rarely highlighted in the literature. We present a case of meningeal melanocytoma of the posterior fossa. Case report A 35‐year‐old male was admitted with complaints of generalized weakness, fever and altered sensorium of 4 days duration. He had a history of recurrent headaches and vomiting for 2 months. A computed tomography scan showed a right cerebello‐pontine angle lesion. At posterior fossa craniotomy, a dark brown to black, soft, dural‐based tumour, located at the right cerebello‐pontine angle was excised. The peri‐operative diagnoses considered were melanotic schwannoma and malignant melanoma. The specimen was sent in saline for intraoperative consultation. The smears prepared were fixed in 95% alcohol and stained with haematoxylin and eosin. On cytological evaluation the smears, were cellular and made

Journal

Cytopathology – Wiley

Published: Feb 1, 2009

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