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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis Sepsis is poorly understood, largely untreatable and frequently fatal. Netea and colleagues assess both mouse sepsis and human sepsis to demonstrate that its late phase is characterized by immunoparalysis and broad metabolic alterations in cells of the immune system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Immunology Springer Journals

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References (69)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
ISSN
1529-2908
eISSN
1529-2916
DOI
10.1038/ni.3398
Publisher site
See Article on Publisher Site

Abstract

Sepsis is poorly understood, largely untreatable and frequently fatal. Netea and colleagues assess both mouse sepsis and human sepsis to demonstrate that its late phase is characterized by immunoparalysis and broad metabolic alterations in cells of the immune system.

Journal

Nature ImmunologySpringer Journals

Published: Mar 7, 2016

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