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/lp/oxford-university-press/hepatic-lesions-of-central-pericellular-fibros-is-in-morbid-obesity-4CBjPfDC3j
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- Publisher
- Oxford University Press
- Copyright
- © American Society of Clinical Pathologists
- ISSN
- 0002-9173
- eISSN
- 1943-7722
- DOI
- 10.1093/ajcp/66.4.684
- Publisher site
- See Article on Publisher Site
Abstract
Histologic findings in liver biopsy specimens obtained from 88 patients before and one and two years after end-to-end jejunoileal bypass are compared. In addition to the expected fatty changes, mild changes of centrilobular, pericellular fibrosis were present in the initial biopsies in 8.6%; a year later they had become apparent in 46%. Portal-central bridging developed in 6.8%, and early micronodular cirrhosis in 3.4% — always in those with central pericellular fibrosis. Electron-microscopic study of prebypass liver biopsies from eight additional patients showed collagen and electron-dense material resembling basement membranes within the spaces of Disse in seven, although only four had light-microscopic evidence of minimal central pericellular fibrosis. The existence of these light- and electronmicroscopic changes before jejunoileal bypass suggests that there is a lesion in morbid obesity that may be exacerbated during the first year alter operation.
Journal
American Journal of Clinical Pathology – Oxford University Press
Published: Oct 1, 1976