Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/t-cell-receptor-repertoire-in-human-germinal-centres-4Ep5pTSLFO
References (35)
-
K. Nakanishi, K. Matsui, S. Kashiwamura, Yasuhiro Nishioka, J. Nomura, Y. Nishimura, N. Sakaguchi, S. Yonehara, K. Higashino, S. Shinka (1996)
IL-4 and anti-CD40 protect against Fas-mediated B cell apoptosis and induce B cell growth and differentiation.International immunology, 8 5
-
David Randolph, Guangming Huang, C. Carruthers, Lindsay Bromley, David Chaplin (1999)
The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.Science, 286 5447
-
Golby (1999)
Human tonsillar germinal center T cells are a diverse and widely disseminated populationEur J Immunol, 29
-
S. Golby, D. Dunn-Walters, J. Spencer (1999)
Human tonsillar germinal center T cells are a diverse and widely disseminated populationEuropean Journal of Immunology, 29
-
Yong‐jun Liu, D. Joshua, Gwyn Williams, Christopher Smith, J. Gordon, I. Maclennan (1989)
Mechanism of antigen-driven selection in germinal centresNature, 342
-
G. Panayi (1997)
T-cell-dependent pathways in rheumatoid arthritis.Current opinion in rheumatology, 9 3
-
Hye-Jung Kim, V. Krenn, G. Steinhauser, C. Berek (1999)
Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis.Journal of immunology, 162 5
-
G. Kelsoe, B. Zheng (1993)
Sites of B-cell activation in vivo.Current opinion in immunology, 5 3
-
M. Spriggs, R. Armitage, L. Strockbine, K. Clifford, B. Macduff, Timothy Sato, Charles Maliszewski, W. Fanslow (1992)
Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretionThe Journal of Experimental Medicine, 176
-
M. Sioud, J. Kjeldsen-Kragh, S. Suleyman, O. Vinje, J. Natvig, Ø. Førre (1992)
Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cellsEuropean Journal of Immunology, 22
-
T. Leanderson, Eva Kallberg, D. Gray (1992)
Expansion, Selection and Mutation of Antigen‐Specific B Cells in Germinal CentersImmunological Reviews, 126
-
F. Bouzahzah, A. Bosseloir, E. Heinen, L. Simar (1995)
Germinal center T cells: analysis of their proliferative capacity.Advances in experimental medicine and biology, 378
-
R. Förster, A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Müller, E. Wolf, M. Lipp (1999)
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid OrgansCell, 99
-
M. Kneba, I. Bolz, B. Linke, W. Hiddemann (1995)
Analysis of rearranged T-cell receptor beta-chain genes by polymerase chain reaction (PCR) DNA sequencing and automated high resolution PCR fragment analysis.Blood, 86 10
-
A. Butch, G. Chung, J. Hoffmann, M. Nahm (1993)
Cytokine expression by germinal center cells.Journal of immunology, 150 1
-
C. Weyand, J. Goronzy (1999)
T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease.Current opinion in rheumatology, 11 3
-
S. Hedrick (1988)
Specificity of the T cell receptor for antigen.Advances in immunology, 43
-
Lars Fugger, A. Svejgaard (1997)
The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients. A combined analysis of data available in the literature.Tissue antigens, 50 5
-
K. Fuller, O. Kanagawa, M. Nahm (1993)
T cells within germinal centers are specific for the immunizing antigen.Journal of immunology, 151 9
-
Anja Schroder, A. Greiner, C. Seyfert, C. Berek (1996)
Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.Proceedings of the National Academy of Sciences of the United States of America, 93 1
-
Y. Choi, Brian Kotzin, Lynne Herron, Jill Callahan, P. Marrack, J. Kappler (1989)
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.Proceedings of the National Academy of Sciences of the United States of America, 86 22
-
M. Bowen, A. Butch, C. Parvin, A. Levine, M. Nahm (1991)
Germinal center T cells are distinct helper-inducer T cells.Human immunology, 31 1
-
I. Randen, O. Mellbye, Ø. Førre, J. Natvig (1995)
The Identification of Germinal Centres and Follicular Dendritic Cell Networks in Rheumatoid Synovial TissueScandinavian Journal of Immunology, 41
-
Z. Dembić, L. Munthe, K. Schenck, C. Mueller, B. Bogen (1998)
Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) alpha chains and promotes positive selection of class II-restricted TCR-transgenic thymocytes.Molecular immunology, 35 1
-
K. Kelly, R. Bucy, M. Nahm (1995)
Germinal center T cells exhibit properties of memory helper T cells.Cellular immunology, 163 2
-
F. Yuda, K. Terashima, M. Dobashi, M. Ishikawa, Y. Imai (1989)
Ultrastructural analysis of HNK-1+ cells in human peripheral blood and lymph nodes.Histology and histopathology, 4 2
-
De Keyser (1995)
The role of T cells in rheumatoid arthritisClin Rheumatol, 14
-
B. Zheng, Shuhua Han, G. Kelsoe (1996)
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1The Journal of Experimental Medicine, 184
-
C. Weyand, E. Bryl, J. Goronzy (2000)
The role of T cells in rheumatoid arthritis.Archivum immunologiae et therapiae experimentalis, 48 5
-
A. Russell, C. Johnston, C. Chew, W. Maksymowych (1997)
Evidence for reduced Th1 function in normal pregnancy: a hypothesis for the remission of rheumatoid arthritis.The Journal of rheumatology, 24 6
-
Classification and Epidemology Rheumatology -
I. Maclennan, D. Gray (1986)
Antigen‐Driven Selection of Virgin and Memory B CellsImmunological Reviews, 91
-
Danyvid Olivares-Villagómez, Yijie Wang, J. Lafaille (1998)
Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune EncephalomyelitisThe Journal of Experimental Medicine, 188
-
T. Sumida, T. Hoa, H. Asahara, T. Hasunuma, K. Nishioka (1997)
T cell receptor of Fas-sensitive T cells in rheumatoid synovium.Journal of immunology, 158 4
-
A. Gulbranson‐Judge, Ian Maclennan (1996)
Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome cEuropean Journal of Immunology, 26
- Publisher
- Wiley
- Copyright
- Copyright © 2001 Wiley Subscription Services
- ISSN
- 0300-9475
- eISSN
- 1365-3083
- DOI
- 10.1046/j.1365-3083.2001.00898.x
- Publisher site
- See Article on Publisher Site
Abstract
A search for an antigen‐driven expansion of T lymphocytes in the inflamed joints in rheumatoid arthritis (RA) patients have been going on for decades. We here analyzed the human germinal centre T‐cell receptor (TCR) Vβ gene usage with polymerase chain reaction (PCR) combined with sequence analysis, to address the question of clonality in tonsils and synovial tissue from RA patients. Our data show a large degree of TCR heterogeneity in both these histological structures. Furthermore, clonally related T cells were found within different closely located germinal centres indicating either an active T‐cell migration between germinal centres (GC) or that a T‐cell clone may seed more than one GC.
Journal
Scandinavian Journal of Immunology – Wiley
Published: Jan 1, 2001