Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Measurement of lung volume in mechanically ventilated monkeys with an ultrasonic flow meter and the nitrogen washout method

Measurement of lung volume in mechanically ventilated monkeys with an ultrasonic flow meter and... ObjectiveMeasurement of functional residual capacity (FRC) during mechanical ventilation is important to standardise respiratory system compliance and adjust the ventilator settings to optimise lung recruitment. In the present study we compared three methods to measure FRC.DesignThe bias flow nitrogen washout technique (FRCN2MC), the multiple breath nitrogen washout (FRCMBNW) and the multiple breath sulphur-hexafluoride washout using the molar mass signal of an ultrasonic flow meter (FRCMBSF6) were compared in six adult monkeys after endotracheal intubation and during spontaneous breathing and mechanical ventilation at three different positive end-expiratory pressure (PEEP) levels of 0, 5 and 10 cmH2O.SettingAnimal research laboratory.ResultsWe found good agreement between all three methods and they all accurately measured changes in FRC when PEEP was increased. The coefficients of variance of the three measurement techniques were in the same range (1.3–9.2%).ConclusionThe measurement of the tracer gas concentration with the molar mass signal of the ultrasonic flow meter provides a good and simple alternative to respiratory mass spectrometer for FRC measurements in ventilated subjects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Intensive Care Medicine Springer Journals

Measurement of lung volume in mechanically ventilated monkeys with an ultrasonic flow meter and the nitrogen washout method

Download PDF
6 pages

Loading next page...
 
/lp/springer-journals/measurement-of-lung-volume-in-mechanically-ventilated-monkeys-with-an-4J7HCSbTby

References (24)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag 2004
Subject
Medicine & Public Health; Intensive / Critical Care Medicine; Anesthesiology; Emergency Medicine; Pneumology/Respiratory System; Pain Medicine; Pediatrics
ISSN
0342-4642
eISSN
1432-1238
DOI
10.1007/s00134-003-2028-0
pmid
14530860
Publisher site
See Article on Publisher Site

Abstract

ObjectiveMeasurement of functional residual capacity (FRC) during mechanical ventilation is important to standardise respiratory system compliance and adjust the ventilator settings to optimise lung recruitment. In the present study we compared three methods to measure FRC.DesignThe bias flow nitrogen washout technique (FRCN2MC), the multiple breath nitrogen washout (FRCMBNW) and the multiple breath sulphur-hexafluoride washout using the molar mass signal of an ultrasonic flow meter (FRCMBSF6) were compared in six adult monkeys after endotracheal intubation and during spontaneous breathing and mechanical ventilation at three different positive end-expiratory pressure (PEEP) levels of 0, 5 and 10 cmH2O.SettingAnimal research laboratory.ResultsWe found good agreement between all three methods and they all accurately measured changes in FRC when PEEP was increased. The coefficients of variance of the three measurement techniques were in the same range (1.3–9.2%).ConclusionThe measurement of the tracer gas concentration with the molar mass signal of the ultrasonic flow meter provides a good and simple alternative to respiratory mass spectrometer for FRC measurements in ventilated subjects.

Journal

Intensive Care Medicine – Springer Journals

Published: Jan 1, 2004

Keywords: Functional residual capacity; Mechanical ventilation; Positive end-expiratory pressure

There are no references for this article.