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SHORT COMMUNICATION: Chemopreventive effects of phenethy1 isothiocyanate on lung and pancreatic tumorigenesis ...

SHORT COMMUNICATION: Chemopreventive effects of phenethy1 isothiocyanate on lung and pancreatic... The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigatedin N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters.Female 5-week-old Syrian golden hamsters were divided into six groups. Animalsin groups 1–3, each consisting of 30 hamsters, were given BOP by twosubcutaneous injections 7 days apart at a dose of 20 mg/kg body weight,plus either 100, 10 or 0 μmol of PEITC in corn oil by gavage 2 h prior toeach BOP treatment, respectively per group. Animals in groups 4 and 5, eachconsisting of 10 hamsters, were given 100 and 10 μmol of PEITC alone incorn oil, and 10 animals in group 6 served as a vehicle control. Animals weresacrificed 52 weeks after the first BOP injection. Both the incidences andmultiplicities of lung adenomas and/ or adenocarcin-omas weresignificantly decreased in a dose-dependent manner by PEITCtreatments(P<0.01 or 0.05). The lung tumorincidences were inhibited by 100% with 100 μmol PEITC and by82% with the 10 μmol dosage. In addition, the high dose of PEITCalso significantly inhibited pancreaticcarcinogenesis(P<0.05)and showed a tendency to lower theincidences of liver and renal tumors, although these effects were notstatistically significant. Under the present experimental conditions, PEITCitself did not cause any apparent toxicity. Our results thus indicates thatPEITC is a remarkably effective chemopreventive agent for the BOP-induced lungand pancreatic tumors in hamsters. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Carcinogenesis Oxford University Press

SHORT COMMUNICATION: Chemopreventive effects of phenethy1 isothiocyanate on lung and pancreatic tumorigenesis ...

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Publisher
Oxford University Press
Copyright
© Oxford University Press
ISSN
0143-3334
eISSN
1460-2180
DOI
10.1093/carcin/17.6.1381
Publisher site
See Article on Publisher Site

Abstract

The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigatedin N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters.Female 5-week-old Syrian golden hamsters were divided into six groups. Animalsin groups 1–3, each consisting of 30 hamsters, were given BOP by twosubcutaneous injections 7 days apart at a dose of 20 mg/kg body weight,plus either 100, 10 or 0 μmol of PEITC in corn oil by gavage 2 h prior toeach BOP treatment, respectively per group. Animals in groups 4 and 5, eachconsisting of 10 hamsters, were given 100 and 10 μmol of PEITC alone incorn oil, and 10 animals in group 6 served as a vehicle control. Animals weresacrificed 52 weeks after the first BOP injection. Both the incidences andmultiplicities of lung adenomas and/ or adenocarcin-omas weresignificantly decreased in a dose-dependent manner by PEITCtreatments(P<0.01 or 0.05). The lung tumorincidences were inhibited by 100% with 100 μmol PEITC and by82% with the 10 μmol dosage. In addition, the high dose of PEITCalso significantly inhibited pancreaticcarcinogenesis(P<0.05)and showed a tendency to lower theincidences of liver and renal tumors, although these effects were notstatistically significant. Under the present experimental conditions, PEITCitself did not cause any apparent toxicity. Our results thus indicates thatPEITC is a remarkably effective chemopreventive agent for the BOP-induced lungand pancreatic tumors in hamsters.

Journal

Carcinogenesis – Oxford University Press

Published: Jun 1, 1996

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