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/lp/oxford-university-press/effect-of-glutathione-on-dna-repair-in-cisplatin-resistant-human-4yvbll5xO7
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- Publisher
- Oxford University Press
- Copyright
- © Oxford University Press
- ISSN
- 0027-8874
- eISSN
- 1460-2105
- DOI
- 10.1093/jnci/81.7.535
- Publisher site
- See Article on Publisher Site
Abstract
Abstract We have studied the effect of glutathione reduction by buthionine sulf-oximine (BSO), a specific inhibitor ofλ -glutamyl cysteine synthetase, on DNA repair after cisplatin damage in an ovarian cancer cell line with invitro induced resistance to cisplatin. In addition, we have examined the effect of aphidicolin, a specific inhibitor of DNA polymerase a, in combination with BSO on cisplatin-associated DNA repair. BSO treatment was found topartially inhibit DNA repair, and the addition of aphidicolin caused nearly a100% inhibition in DNA repair activity. Treatment of cells with glutathioneester after BSO resulted in complete recovery of DNA repair activity or par-tial recovery if aphidicolin was present. The significance of these results to the chemosensitizing effects of BSO medi-ated glutathione reduction is discussed. [J Natl Cancer Inst 81:535-539, 1989] This content is only available as a PDF. © Oxford University Press
Journal
JNCI: Journal of the National Cancer Institute – Oxford University Press
Published: Apr 5, 1989