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References (20)
-
A. Rook, J. Kehrl, L. Wakefield, A. Roberts, M. Sporn, D. Burlington, H. Lane, A. Fauci (1986)
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.Journal of immunology, 136 10
-
A. Granelli‐Piperno, K. Inaba, R. Steinman (1984)
Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin AThe Journal of Experimental Medicine, 160
-
(1986)
Transformin g growth factor-S is an important immunomodulatory protein for human ,B lymphocytes -
H. Ristow (1986)
BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America, 83 15
-
T. Beveridge (1986)
Clinical transplantation--overview.Progress in allergy, 38
-
Y. Niwa, T. Kano, S. Taniguchi, Y. Miyachi, T. Sakane (1986)
Effect of cyclosporin A on the membrane-associated events in human leukocytes with special reference to the similarity with dexamethasone.Biochemical pharmacology, 35 6
-
S. Vadhan-Raj, A. Al-Katib, R. Bhalla, L. Pelus, C. Nathan, S. Sherwin, H. Oettgen, S. Krown (1986)
Phase I trial of recombinant interferon gamma in cancer patients.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 4 2
-
S. Kramer, M. Carver (1986)
Serum-free in vitro bioassay for the detection of tumor necrosis factor.Journal of immunological methods, 93 2
-
A. Granelli‐Piperno, L. Andrus, R. Steinman (1986)
Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin AThe Journal of Experimental Medicine, 163
-
(1986)
Transformin g growth factor-,B: biological function and chemical structure -
W. Prince, K. Harder, S. Saks, B. Reed, A. Chen, A. Jones (1987)
ELISA for quantitation of tumor necrosis factor-alpha in serum.Journal of pharmaceutical and biomedical analysis, 5 8
-
J. Kehrl, L. Wakefield, A. Roberts, S. Jakowlew, M. Alvarez-Mon, R. Derynck, M. Sporn, A. Fauci (1986)
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growthThe Journal of Experimental Medicine, 163
-
P. Gray, D. Leung, D. Pennica, E. Yelverton, R. Najarian, C. Simonsen, R. Derynck, P. Sherwood, D. Wallace, S. Berger, A. Levinson, D. Goeddel (1982)
Expression of human immune interferon cDNA in E. coli and monkey cellsNature, 295
-
(1986)
Natura l killer - sensitive targets stimulate production of TNF - a but not TNF - , B ( lymphotoxin ) by highly purified human peripheral blood large granular lymphocytes -
(1985)
Effect of interleukin - 2 , interferon - y , and mitogens on the production of tumor necrosis factors - a and - , B -
P. Gray, D. Goeddel (1983)
Cloning and expression of murine immune interferon cDNA.Proceedings of the National Academy of Sciences of the United States of America, 80 19
-
G. Klaus (1981)
The effects of cyclosporin A on the immune system.Immunology today, 2 5
-
C. Dinarello, J. Cannon, S. Wolff, H. Bernheim, B. Beutler, A. Cerami, I. Figari, M. Palladino, John 'connor (1986)
Tumor Necrosis Factor (cachectin) Is an Endogenous Pyrogen and Induces Production Interleukin 1 Of -
(1986)
Effect s of interferon--y and tumor necrosis factora on the expression of an la antigen on a murine macrophage cell line -
(1986)
Regulation ofcytokine production and class II antigen expression by transforming growth factor-beta
- Publisher
- Rockefeller University Press
- Copyright
- © 1987 Rockefeller University Press
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.166.2.571
- Publisher site
- See Article on Publisher Site
Abstract
We investigated the ability of cyclosporin A (CsA) and transforming growth factor beta (TGF-beta) to modulate the production of TNF-alpha and TNF-beta and IFN-gamma by unseparated, nonadherent, and adherent PBMC. Treatment of unseparated PBMC with CsA resulted in a significant dose-dependent inhibition of all three cytokines ranging from greater than 90% inhibition for IFN-gamma and TNF-beta, to approximately 70% for TNF-alpha. Pretreatment of unseparated or nonadherent PBMC with TGF-beta inhibited the production of IFN-gamma by 60-70%. However, the inhibition of TNF-alpha and TNF-beta production by these cells was only minimally affected, and at 0.1-1 ng/ml TGF-beta could enhance TNF-alpha production by unseparated PBMC. In contrast, pretreatment of adherent PBMC with TGF-beta inhibited the production of TNF-alpha by approximately 60%. TGF-beta also inhibited both TNF-alpha production and tumor cell cytotoxicity mediated by murine peritoneal-derived macrophages. These observations indicate that the biological effects of CsA and TGF-beta on immune functions are of a wider range than previously reported.
Journal
The Journal of Experimental Medicine – Rockefeller University Press
Published: Aug 1, 1987