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Epizootic of Tularemia in an Outdoor Housed Group of Cynomolgus Monkeys (Macaca fascicularis)

Epizootic of Tularemia in an Outdoor Housed Group of Cynomolgus Monkeys (Macaca fascicularis) Tularemia is a highly contagious infectious zoonosis, transmissible by inoculation,ingestion, or inhalation of the infectious agent Francisellatularensis. The disease is perpetuated by infected rodents, blood-suckingarthropods, and by contaminated water. Therefore, nonhuman primates housed outdoorsmay be at risk for exposure. An epizootic of F. tularensis occurredin an indoor/outdoor-housed group of cynomolgus monkeys (Macacafascicularis) at the German Primate Center. Tularemia was diagnosed in 18out of 35 animals within a period of 2 years. Six animals died with unspecificclinical symptoms; 12 animals developed seroconversion and were still alive.Pathologic findings were similar in all monkeys that died and resembled the clinicalpicture of the human disease, including an ulceroglandular syndrome with locallymphadenopathy, gingivostomatitis, and systemic spread, with manifestations such assubacute necrotizing hepatitis, granulomatous splenitis, and pneumonia. Tularemia wasdiagnosed by culture, real-time polymerase chain reaction, and ELISA techniques. Thisis the largest outbreak in nonhuman primates and the first report of tularemia incynomolgus monkeys. An overview of the recent literature about tularemia in nonhumanprimates is given. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Pathology SAGE

Epizootic of Tularemia in an Outdoor Housed Group of Cynomolgus Monkeys (Macaca fascicularis)

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References (17)

Publisher
SAGE
Copyright
© 2007 American College of Veterinary Pathologists
ISSN
0300-9858
eISSN
1544-2217
DOI
10.1354/vp.44-3-327
pmid
17491074
Publisher site
See Article on Publisher Site

Abstract

Tularemia is a highly contagious infectious zoonosis, transmissible by inoculation,ingestion, or inhalation of the infectious agent Francisellatularensis. The disease is perpetuated by infected rodents, blood-suckingarthropods, and by contaminated water. Therefore, nonhuman primates housed outdoorsmay be at risk for exposure. An epizootic of F. tularensis occurredin an indoor/outdoor-housed group of cynomolgus monkeys (Macacafascicularis) at the German Primate Center. Tularemia was diagnosed in 18out of 35 animals within a period of 2 years. Six animals died with unspecificclinical symptoms; 12 animals developed seroconversion and were still alive.Pathologic findings were similar in all monkeys that died and resembled the clinicalpicture of the human disease, including an ulceroglandular syndrome with locallymphadenopathy, gingivostomatitis, and systemic spread, with manifestations such assubacute necrotizing hepatitis, granulomatous splenitis, and pneumonia. Tularemia wasdiagnosed by culture, real-time polymerase chain reaction, and ELISA techniques. Thisis the largest outbreak in nonhuman primates and the first report of tularemia incynomolgus monkeys. An overview of the recent literature about tularemia in nonhumanprimates is given.

Journal

Veterinary Pathology – SAGE

Published: May 1, 2007

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