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Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Neuroscience Springer Journals

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

Andrew, D.; Craig, A. D.
Nature Neuroscience , Volume 4 (1) – Jan 1, 2001
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References (38)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Nature America Inc.
Subject
Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
ISSN
1097-6256
eISSN
1546-1726
DOI
10.1038/82924
Publisher site
See Article on Publisher Site

Abstract

We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally.

Journal

Nature Neuroscience – Springer Journals

Published: Jan 1, 2001

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