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ROLE OF GELATINOUS SUBSTANCE OF SPINAL CORD IN CONDUCTION OF PAIN

ROLE OF GELATINOUS SUBSTANCE OF SPINAL CORD IN CONDUCTION OF PAIN Abstract THE PATHS of the dorsal root fibers into Lissauer's zone and the dorsal funiculus of the spinal cord are well established. The manner of the termination of these fibers within the gray matter of the spinal cord and the pattern of the connecting neurons are not so well understood. This is particularly true of the human spinal cord. Although this problem has been studied by Ramón y Cajal,1 Ranson,2 and others, there are still wide gaps in our knowledge of these connections. The majority of the studies on this subject have been based on the lower vertebrate forms, such as the chick and cat, with few observations on the higher mammals and man. Since the early literature on this subject has been reviewed by Barker3; Ranson4; Massazza5; Bok,6 and Ariëns Kappers, Huber, and Crosby,7 only the more recent investigations will be discussed. MATERIALS References 1. Ramón y Cajal, S.: Histologie du système nerveux de l'homme et des vertébrés , translated from the Spanish by L. Azoulay, Paris, A. Maloine, 1909, Vol. 1. 2. Ranson, S. W.: Course Within the Spinal Cord of the Non-Medullated Fibers of the Dorsal Roots: A Study of Lissauer's Tract in the Cat , J. Comp. Neurol. 23:259-281, 1913.Crossref 3. Barker, L. F.: The Nervous System and Its Constituent Neurones, Designed for the Use of Practitioners of Medicine and of Students of Medicine and Psychology , New York, D. Appleton & Co., 1899. 4. Ranson, S. W.: (a) The Tract of Lissauer and the Substantia Gelatinosa Rolandi , Am. J. Anat. 16:97-126, 1914Crossref 5. footnote 2. 6. Massazza, A.: La citoarchitettonica del midollo spinale umano , Arch. anat., histol. et embryol. 3:115-192, 1924. 7. Bok, S. T.: Das Rückenmark, in von Möllendorff, W., Editor: Handbuch der mikroskopischen Anatomie des Menschen , Berlin, Julius Springer, 1928, Vol. 4, pp. 478-578. 8. Ariëns Kappers, C. U.; Huber, G. C., and Crosby, E. C.: The Comparative Anatomy of the Nervous System of Vertebrates, Including Man , Vol. I, New York, The Macmillan Company, 1936. 9. Fox, C. A.; Ubeda-Purkiss, M.; Ihrig, H. K., and Biagioli, D.: Zinc Chromate Modification of the Golgi Technique , Anat. Rec. 106:303, 1950. 10. Pearson, A. A.: A Modification of the Golgi Technique , Anat. Rec. 109:405-406, 1951. 11. Conel, J. L.: Postnatal Development of the Human Cerebral Cortex , Vol. I, The Cortex of the Newborn, Cambridge, Mass., Harvard University Press, 1939. 12. Bruce, A.: A Topographical Atlas of the Spinal Cord , London, Williams & Norgate, 1901. 13. Jacobsohn, L.: Über die Kerne des menschlichen Rückenmarkes , Berlin, Verlag der Königlich-bayerische Akademie der Wissenschaften, in Kommission bei Georg Reimer, 1908. 14. Earle, K. M.: Tract of Lissauer and Its Possible Relation to the Pain Pathway , J. Comp. Neurol. 96:93-111, 1952.Crossref 15. Ramón y Cajal, S.: Histology , revised by J. F. Tello-Múñoz, translated from the 10th Spanish Edition by M. Fernán-Núñez, Baltimore, William Wood & Company, 1933. 16. Massazza.5 17. Bok.6 18. Jacobsohn.12 19. Woollard, H. H.; Weddell, G., and Harpman, J. A.: Observations on the Neurohistological Basis of Cutaneous Pain , J. Anat. 74:413-440, 1940. 20. Larsell, O.: Anatomy of the Nervous System , Ed. 2, New York, Appleton-Century-Crofts, Inc., 1951. 21. Weddell, G.: Pattern of Cutaneous Innervation in Relation to Cutaneous Sensibility , J. Anat. 75:346-367, 1941. 22. Walshe, F. M. R.: Anatomy and Physiology of Cutaneous Sensibility: A Critical Review , Brain 65:48-112, 1942.Crossref 23. Gasser, H. S.: Pain-Producing Impulses in Peripheral Nerves , A. Res. Nerv. & Ment. Dis. Proc. 23:44-62, 1943. 24. Wolff, H. G., and Wolf, S.: Pain, American Lectures in Physiology , Springfield, Ill., Charles C Thomas, Publisher, 1948. 25. Forbus, W. D.: Reaction to Injury: Pathology for Students of Disease Based on the Functional and Morphological Responses of Tissues to Injurious Agents , Baltimore, Williams & Wilkins Company, 1943. 26. Pochin, E. E.: Delay of Pain Perception in Tabes Dorsalis , Clin. Sc. 3:191-196, 1938. 27. Ranson, S. W.: Unmyelinated Nerve-Fibers as Conductors of Protopathic Sensation , Brain 38:381-389, 1915. 28. Ranson, S. W., and Billingsley, P. R.: Conduction of Painful Afferent Impulses in the Spinal Nerves , Am. J. Physiol. 40:571-584, 1916. 29. Szentagothai, J., and Kiss, T.: Projection of Dermatomes on the Substantia Gelatinosa , Arch. Neurol. & Psychiat. 62:734-744, 1949. 30. Foerster, O., and Gagel, O.: Die Vorderseitenstrangdurchschneidung beim Menschen: Eine klinisch-patho-physiologisch-anatomische Studie , Ztschr. ges. Neurol. u. Psychiat. 138:1-92, 1932. 31. Kuru, M.: Die Veränderung im Zentralnervensystem bei den 2 Fällen von "partieller" Chordotomie: Ein Beitrag zur Frage der Ursprungszellen des Tractus spinotectalis et -thalamicus , Gann 32:1-25, 1938. 32. Walker, A. E.: The Spinothalamic Tract in Man , Arch. Neurol. & Psychiat. 43:284-298, 1940. 33. Olszewski, J.: On the Anatomical and Functional Organization of the Spinal Trigeminal Nucleus , J. Comp. Neurol. 92:401-413, 1950. 34. Livingston, W. K.: Pain Mechanisms: A Physiologic Interpretation of Causalgia and Its Related States , New York, The Macmillan Company, 1943. 35. Ruch, T. C.: Visceral Sensation and Referred Pain, in Howell's Textbook of Physiology , Ed. 16, edited by J. F. Fulton, Philadelphia, W. B. Saunders Company, 1949, Chap. 19, pp. 360-374. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

ROLE OF GELATINOUS SUBSTANCE OF SPINAL CORD IN CONDUCTION OF PAIN

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1952.02320220092011
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Abstract

Abstract THE PATHS of the dorsal root fibers into Lissauer's zone and the dorsal funiculus of the spinal cord are well established. The manner of the termination of these fibers within the gray matter of the spinal cord and the pattern of the connecting neurons are not so well understood. This is particularly true of the human spinal cord. Although this problem has been studied by Ramón y Cajal,1 Ranson,2 and others, there are still wide gaps in our knowledge of these connections. The majority of the studies on this subject have been based on the lower vertebrate forms, such as the chick and cat, with few observations on the higher mammals and man. Since the early literature on this subject has been reviewed by Barker3; Ranson4; Massazza5; Bok,6 and Ariëns Kappers, Huber, and Crosby,7 only the more recent investigations will be discussed. MATERIALS References 1. Ramón y Cajal, S.: Histologie du système nerveux de l'homme et des vertébrés , translated from the Spanish by L. Azoulay, Paris, A. Maloine, 1909, Vol. 1. 2. Ranson, S. W.: Course Within the Spinal Cord of the Non-Medullated Fibers of the Dorsal Roots: A Study of Lissauer's Tract in the Cat , J. Comp. Neurol. 23:259-281, 1913.Crossref 3. Barker, L. F.: The Nervous System and Its Constituent Neurones, Designed for the Use of Practitioners of Medicine and of Students of Medicine and Psychology , New York, D. Appleton & Co., 1899. 4. Ranson, S. W.: (a) The Tract of Lissauer and the Substantia Gelatinosa Rolandi , Am. J. Anat. 16:97-126, 1914Crossref 5. footnote 2. 6. Massazza, A.: La citoarchitettonica del midollo spinale umano , Arch. anat., histol. et embryol. 3:115-192, 1924. 7. Bok, S. T.: Das Rückenmark, in von Möllendorff, W., Editor: Handbuch der mikroskopischen Anatomie des Menschen , Berlin, Julius Springer, 1928, Vol. 4, pp. 478-578. 8. Ariëns Kappers, C. U.; Huber, G. C., and Crosby, E. C.: The Comparative Anatomy of the Nervous System of Vertebrates, Including Man , Vol. I, New York, The Macmillan Company, 1936. 9. Fox, C. A.; Ubeda-Purkiss, M.; Ihrig, H. K., and Biagioli, D.: Zinc Chromate Modification of the Golgi Technique , Anat. Rec. 106:303, 1950. 10. Pearson, A. A.: A Modification of the Golgi Technique , Anat. Rec. 109:405-406, 1951. 11. Conel, J. L.: Postnatal Development of the Human Cerebral Cortex , Vol. I, The Cortex of the Newborn, Cambridge, Mass., Harvard University Press, 1939. 12. Bruce, A.: A Topographical Atlas of the Spinal Cord , London, Williams & Norgate, 1901. 13. Jacobsohn, L.: Über die Kerne des menschlichen Rückenmarkes , Berlin, Verlag der Königlich-bayerische Akademie der Wissenschaften, in Kommission bei Georg Reimer, 1908. 14. Earle, K. M.: Tract of Lissauer and Its Possible Relation to the Pain Pathway , J. Comp. Neurol. 96:93-111, 1952.Crossref 15. Ramón y Cajal, S.: Histology , revised by J. F. Tello-Múñoz, translated from the 10th Spanish Edition by M. Fernán-Núñez, Baltimore, William Wood & Company, 1933. 16. Massazza.5 17. Bok.6 18. Jacobsohn.12 19. Woollard, H. H.; Weddell, G., and Harpman, J. A.: Observations on the Neurohistological Basis of Cutaneous Pain , J. Anat. 74:413-440, 1940. 20. Larsell, O.: Anatomy of the Nervous System , Ed. 2, New York, Appleton-Century-Crofts, Inc., 1951. 21. Weddell, G.: Pattern of Cutaneous Innervation in Relation to Cutaneous Sensibility , J. Anat. 75:346-367, 1941. 22. Walshe, F. M. R.: Anatomy and Physiology of Cutaneous Sensibility: A Critical Review , Brain 65:48-112, 1942.Crossref 23. Gasser, H. S.: Pain-Producing Impulses in Peripheral Nerves , A. Res. Nerv. & Ment. Dis. Proc. 23:44-62, 1943. 24. Wolff, H. G., and Wolf, S.: Pain, American Lectures in Physiology , Springfield, Ill., Charles C Thomas, Publisher, 1948. 25. Forbus, W. D.: Reaction to Injury: Pathology for Students of Disease Based on the Functional and Morphological Responses of Tissues to Injurious Agents , Baltimore, Williams & Wilkins Company, 1943. 26. Pochin, E. E.: Delay of Pain Perception in Tabes Dorsalis , Clin. Sc. 3:191-196, 1938. 27. Ranson, S. W.: Unmyelinated Nerve-Fibers as Conductors of Protopathic Sensation , Brain 38:381-389, 1915. 28. Ranson, S. W., and Billingsley, P. R.: Conduction of Painful Afferent Impulses in the Spinal Nerves , Am. J. Physiol. 40:571-584, 1916. 29. Szentagothai, J., and Kiss, T.: Projection of Dermatomes on the Substantia Gelatinosa , Arch. Neurol. & Psychiat. 62:734-744, 1949. 30. Foerster, O., and Gagel, O.: Die Vorderseitenstrangdurchschneidung beim Menschen: Eine klinisch-patho-physiologisch-anatomische Studie , Ztschr. ges. Neurol. u. Psychiat. 138:1-92, 1932. 31. Kuru, M.: Die Veränderung im Zentralnervensystem bei den 2 Fällen von "partieller" Chordotomie: Ein Beitrag zur Frage der Ursprungszellen des Tractus spinotectalis et -thalamicus , Gann 32:1-25, 1938. 32. Walker, A. E.: The Spinothalamic Tract in Man , Arch. Neurol. & Psychiat. 43:284-298, 1940. 33. Olszewski, J.: On the Anatomical and Functional Organization of the Spinal Trigeminal Nucleus , J. Comp. Neurol. 92:401-413, 1950. 34. Livingston, W. K.: Pain Mechanisms: A Physiologic Interpretation of Causalgia and Its Related States , New York, The Macmillan Company, 1943. 35. Ruch, T. C.: Visceral Sensation and Referred Pain, in Howell's Textbook of Physiology , Ed. 16, edited by J. F. Fulton, Philadelphia, W. B. Saunders Company, 1949, Chap. 19, pp. 360-374.

Journal

A.M.A. Archives of Neurology & Psychiatry – American Medical Association

Published: Oct 1, 1952

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