Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Teplitski, R. Goodier, B. Ahmer (2003)
Pathways Leading from BarA/SirA to Motility andVirulence Gene Expression inSalmonellaJournal of Bacteriology, 185
C. Johnston, D. Pegues, C. Hueck, Catherine Lee, Samuel Miller (1996)
Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response‐regulator superfamilyMolecular Microbiology, 22
R. Vance, Jun Zhu, J. Mekalanos (2003)
A Constitutively Active Variant of the Quorum-Sensing Regulator LuxO Affects Protease Production and Biofilm Formation in Vibrio choleraeInfection and Immunity, 71
A. Pernestig, O. Melefors, D. Georgellis (2001)
Identification of UvrY as the Cognate Response Regulator for the BarA Sensor Kinase in Escherichia coli *The Journal of Biological Chemistry, 276
S. Nakayama, A. Kushiro, T. Asahara, R. Tanaka, Lan Hu, D. Kopecko, Haruo Watanabe (2003)
Activation of hilA expression at low pH requires the signal sensor CpxA, but not the cognate response regulator CpxR, in Salmonella enterica serovar Typhimurium.Microbiology, 149 Pt 10
V. DiRita, Melody Neely, Ronald Taylor, Paula Bruss (1996)
Differential expression of the ToxR regulon in classical and E1 Tor biotypes of Vibrio cholerae is due to biotype-specific control over toxT expression.Proceedings of the National Academy of Sciences of the United States of America, 93 15
S. Chatfield, C. Dorman, C. Hayward, G. Dougan (1991)
Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivoInfection and Immunity, 59
P. Oyston, N. Dorrell, K. Williams, Shu-Rui Li, Michael Green, R. Titball, B. Wren (2000)
The Response Regulator PhoP Is Important for Survival under Conditions of Macrophage-Induced Stress and Virulence in Yersinia pestisInfection and Immunity, 68
A. Eriksson, R. Andersson, M. Pirhonen, E. Palva (1998)
Two-component regulators involved in the global control of virulence in Erwinia carotovora subsp. carotovora.Molecular plant-microbe interactions : MPMI, 11 8
Veronica Miller, J. Mekalanos (1988)
A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxRJournal of Bacteriology, 170
J. Gunn, S. Ryan, J. Velkinburgh, R. Ernst, S. Miller (2000)
Genetic and Functional Analysis of a PmrA-PmrB-Regulated Locus Necessary for Lipopolysaccharide Modification, Antimicrobial Peptide Resistance, and Oral Virulence of Salmonella entericaSerovar TyphimuriumInfection and Immunity, 68
S. Nakayama, Haruo Watanabe (1998)
Identification of cpxR as a Positive Regulator Essential for Expression of the Shigella sonnei virF GeneJournal of Bacteriology, 180
J. Shea, M. Hensel, Colin Gleeson, D. Holden (1996)
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.Proceedings of the National Academy of Sciences of the United States of America, 93 6
D. Flego, R. Marits, A. Eriksson, V. Kõiv, Maj-Britt Karlsson, R. Heikinheimo, E. Palva (2000)
A two-component regulatory system, pehR-pehS, controls endopolygalacturonase production and virulence in the plant pathogen Erwinia carotovora subsp. carotovora.Molecular plant-microbe interactions : MPMI, 13 4
M. Wösten, L. Kox, S. Chamnongpol, F. Soncini, E. Groisman (2000)
A Signal Transduction System that Responds to Extracellular IronCell, 103
T. Parish, Debbie Smith, Gretta Roberts, J. Betts, N. Stoker (2003)
The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence.Microbiology, 149 Pt 6
Shengmei Jiang, M. Cieslewicz, D. Kasper, M. Wessels (2005)
Regulation of Virulence by a Two-Component System in Group B StreptococcusJournal of Bacteriology, 187
Darren Schuhmacher, K. Klose (1999)
Environmental Signals Modulate ToxT-Dependent Virulence Factor Expression in Vibrio choleraeJournal of Bacteriology, 181
S. Lindgren, I. Stojiljković, F. Heffron (1996)
Macrophage killing is an essential virulence mechanism of Salmonella typhimurium.Proceedings of the National Academy of Sciences of the United States of America, 93 9
A. Llama-Palacios, E. López-Solanilla, C. Poza-Carrión, F. Garcı́a-Olmedo, P. Rodríguez-Palenzuela (2003)
The Erwinia chrysanthemi phoP‐phoQ operon plays an important role in growth at low pH, virulence and bacterial survival in plant tissueMolecular Microbiology, 49
M Fernández-Mora, JL Puente, E Calva (2004)
OmpR and LeuO regulate the Salmonella typhi ompS2 quiescent porin geneJ Bacteriol, 186
Gretchen Champion, M. Neely, Molly Brennan, V. DiRita (1997)
A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strainsMolecular Microbiology, 23
K. Panthel, Patricia Dietz, R. Haas, D. Beier (2003)
Two-Component Systems of Helicobacter pylori Contribute to Virulence in a Mouse Infection ModelInfection and Immunity, 71
J. Schär, A. Sickmann, D. Beier (2005)
Phosphorylation-Independent Activity of Atypical Response Regulators of Helicobacter pyloriJournal of Bacteriology, 187
S. Nakayama, Haruo Watanabe (1995)
Involvement of cpxA, a sensor of a two-component regulatory system, in the pH-dependent regulation of expression of Shigella sonnei virF geneJournal of Bacteriology, 177
M. Glickman, J. Cox, W. Jacobs (2000)
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.Molecular cell, 5 4
M. Bader, W. Navarre, Whitney Shiau, H. Nikaido, J. Frye, Michael McClelland, F. Fang, Samuel Miller (2003)
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptidesMolecular Microbiology, 50
Marie‐Cécile Lamy, M. Zouine, J. Fert, M. Vergassola, E. Couvé, E. Pellegrini, P. Glaser, F. Kunst, T. Msadek, P. Trieu-Cuot, C. Poyart (2004)
CovS/CovR of group B streptococcus: a two‐component global regulatory system involved in virulenceMolecular Microbiology, 54
D. Herrington, Robert Hall, G. Losonsky, J. Mekalanos, I. Taylor, M. Levine (1988)
Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humansThe Journal of Experimental Medicine, 168
Jun Zhu, Melissa Miller, R. Vance, M. Dziejman, B. Bassler, J. Mekalanos (2002)
Quorum-sensing regulators control virulence gene expression in Vibrio choleraeProceedings of the National Academy of Sciences of the United States of America, 99
L. Rickman, J. Saldanha, D. Hunt, D. Hoar, M. Colston, J. Millar, R. Buxton (2004)
A two-component signal transduction system with a PAS domain-containing sensor is required for virulence of Mycobacterium tuberculosis in mice.Biochemical and biophysical research communications, 314 1
S. Miller, A. Kukral, J. Mekalanos (1989)
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.Proceedings of the National Academy of Sciences of the United States of America, 86 13
J. Garmendia, C. Beuzón, Javier Ruiz-Albert, D. Holden (2003)
The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system.Microbiology, 149 Pt 9
Anthea Lee, C. Detweiler, S. Falkow (2000)
OmpR Regulates the Two-Component System SsrA-SsrB in Salmonella Pathogenicity Island 2Journal of Bacteriology, 182
加藤 明宣, E. Groisman (2004)
Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor.Genes & development, 18 18
K. Skorupski, R. Taylor (1997)
Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuliMolecular Microbiology, 25
E. Véscovi, F. Soncini, E. Groisman (1996)
Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella VirulenceCell, 84
K. Brzostek, A. Raczkowska, A. Zasada (2003)
The osmotic regulator OmpR is involved in the response of Yersinia enterocolitica O:9 to environmental stresses and survival within macrophages.FEMS microbiology letters, 228 2
J. Mitobe, E. Arakawa, Haruo Watanabe (2005)
A Sensor of the Two-Component System CpxA Affects Expression of the Type III Secretion System through Posttranscriptional Processing of InvEJournal of Bacteriology, 187
T. Zahrt, Christopher Wozniak, Denise Jones, Andrea Trevett (2003)
Functional Analysis of theMycobacterium tuberculosis MprAB Two-Component SignalTransductionSystemInfection and Immunity, 71
N. Engleberg, A. Heath, Alita Miller, Clarise Rivera, V. DiRita (2001)
Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection.The Journal of infectious diseases, 183 7
Jovanka Voyich, D. Sturdevant, K. Braughton, Scott Kobayashi, B. Lei, K. Virtaneva, D. Dorward, J. Musser, F. DeLeo (2003)
Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytesProceedings of the National Academy of Sciences of the United States of America, 100
N. Dorrell, Shu Li, P. Everest, Gordon Dougan, B. Wren (1998)
Construction and characterisation of a Yersinia enterocolitica O:8 ompR mutant.FEMS microbiology letters, 165 1
J. Yarwood, J. McCormick, P. Schlievert (2001)
Identification of a Novel Two-Component Regulatory System That Acts in Global Regulation of Virulence Factors ofStaphylococcus aureusJournal of Bacteriology, 183
R. Novick, H. Ross, S. Projan, J. Kornblum, B. Kreiswirth, S. Moghazeh (1993)
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.The EMBO Journal, 12
S. Gupta, R. Chowdhury (1997)
Bile affects production of virulence factors and motility of Vibrio choleraeInfection and Immunity, 65
Melissa Miller, K. Skorupski, Derrick Lenz, R. Taylor, B. Bassler (2002)
Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio choleraeCell, 110
M. Flores-Valdez, J. Puente, E. Calva (2003)
Negative Osmoregulation of the Salmonella ompS1 Porin Gene Independently of OmpR in an hns BackgroundJournal of Bacteriology, 185
A. Pernestig, D. Georgellis, T. Romeo, Kazushi Suzuki, Henrik Tomenius, S. Normark, O. Melefors (2003)
The Escherichia coli BarA-UvrY Two-Component System Is Needed for Efficient Switching between Glycolytic and Gluconeogenic Carbon SourcesJournal of Bacteriology, 185
Maria Bernardini, M. Sanna, Annick Fontaine, P. Sansonetti (1993)
OmpC is involved in invasion of epithelial cells by Shigella flexneriInfection and Immunity, 61
Wendy Veal‐Carr, S. Stibitz (2004)
Demonstration of differential virulence gene promoter activation in vivo in Bordetella pertussis using RIVETMolecular Microbiology, 55
R. Oropeza, C. Sampieri, J. Puente, E. Calva (1999)
Negative and positive regulation of the non‐osmoregulated ompS1 porin gene in Salmonella typhi : a novel regulatory mechanism that involves OmpRMolecular Microbiology, 32
Charles Kim, S. Falkow (2004)
Delineation of Upstream Signaling Events in the Salmonella Pathogenicity Island 2 Transcriptional Activation PathwayJournal of Bacteriology, 186
M. Hensel, J. Shea, S. Waterman, R. Mundy, T. Nikolaus, G. Banks, A. Vázquez-Torres, Colin Gleeson, F. Fang, D. Holden (1998)
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophagesMolecular Microbiology, 30
A. Pragman, J. Yarwood, T. Tripp, P. Schlievert (2004)
Characterization of Virulence Factor Regulation by SrrAB, a Two-Component System in Staphylococcus aureusJournal of Bacteriology, 186
R. Novick (2003)
Autoinduction and signal transduction in the regulation of staphylococcal virulenceMolecular Microbiology, 48
D. Hung, J. Mekalanos (2005)
Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.Proceedings of the National Academy of Sciences of the United States of America, 102 8
C. Boon, T. Dick (2002)
Mycobacterium bovis BCG Response Regulator Essential for Hypoxic DormancyJournal of Bacteriology, 184
B. Ahmer, J. Reeuwijk, P. Watson, T. Wallis, F. Heffron (1999)
Salmonella SirA is a global regulator of genes mediating enteropathogenesisMolecular Microbiology, 31
Jens Grabenstein, M. Marceau, C. Pujol, M. Simonet, J. Bliska (2004)
The Response Regulator PhoP of Yersinia pseudotuberculosis Is Important for Replication in Macrophages and for VirulenceInfection and Immunity, 72
Charles Dorman, S. Chatfield, Christopher Higgins, C. Hayward, G. Dougan (1989)
Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivoInfection and Immunity, 57
B. Fournier, D. Hooper (2000)
A New Two-Component Regulatory System Involved in Adhesion, Autolysis, and Extracellular Proteolytic Activity ofStaphylococcus aureusJournal of Bacteriology, 182
Michael Federle, K. McIver, J. Scott (1999)
A Response Regulator That Represses Transcription of Several Virulence Operons in the Group A StreptococcusJournal of Bacteriology, 181
M. Graham, L. Smoot, C. Migliaccio, K. Virtaneva, D. Sturdevant, S. Porcella, Michael Federle, G. Adams, J. Scott, J. Musser (2002)
Virulence control in group A Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modelingProceedings of the National Academy of Sciences of the United States of America, 99
D. Beier, R. Frank (2000)
Molecular Characterization of Two-Component Systems of Helicobacter pyloriJournal of Bacteriology, 182
J. Hoch, T. Silhavy (1995)
Two-component signal transduction
F. Soncini, E. Groisman (1996)
Two-component regulatory systems can interact to process multiple environmental signalsJournal of Bacteriology, 178
M. Hensel, J. Shea, Colin Gleeson, Michael Jones, E. Dalton, D. Holden (1995)
Simultaneous identification of bacterial virulence genes by negative selection.Science, 269 5222
E. Pérez, S. Samper, Y. Bordas, C. Guilhot, B. Gicquel, Carlos Martín (2001)
An essential role for phoP in Mycobacterium tuberculosis virulenceMolecular Microbiology, 41
A. Giraudo, Cecilia Mansilla, A. Chan, C. Raspanti, R. Nagel (2003)
Studies on the Expression of Regulatory Locus sae in Staphylococcus aureusCurrent Microbiology, 46
H. Hyytiäinen, S. Sjöblom, T. Palomäki, A. Tuikkala, E. Palva (2003)
The PmrA‐PmrB two‐component system responding to acidic pH and iron controls virulence in the plant pathogen Erwinia carotovora ssp. carotovoraMolecular Microbiology, 50
L. Hancock, M. Perego (2002)
Two-Component Signal Transduction in Enterococcus faecalisJournal of Bacteriology, 184
L. Kier, R. Weppelman, B. Ames (1979)
Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genesJournal of Bacteriology, 138
Yaya Cui, A. Chatterjee, A. Chatterjee (2001)
Effects of the two-component system comprising GacA and GacS of Erwinia carotovora subsp. carotovora on the production of global regulatory rsmB RNA, extracellular enzymes, and harpinEcc.Molecular plant-microbe interactions : MPMI, 14 4
Vandana Malhotra, Deepak Sharma, V. Ramanathan, H. Shakila, D. Saini, S. Chakravorty, T. Das, Qing Li, R. Silver, P. Narayanan, J. Tyagi (2004)
Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis.FEMS microbiology letters, 231 2
Y. Breton, G. Boël, A. Benachour, H. Prévost, Y. Auffray, A. Rincé (2003)
Molecular characterization of Enterococcus faecalis two-component signal transduction pathways related to environmental stresses.Environmental microbiology, 5 5
A. Heath, V. DiRita, N. Barg, N. Engleberg (1999)
A Two-Component Regulatory System, CsrR-CsrS, Represses Expression of Three Streptococcus pyogenesVirulence Factors, Hyaluronic Acid Capsule, Streptolysin S, and Pyrogenic Exotoxin BInfection and Immunity, 67
F. Teng, Ling Wang, Kavindra Singh, B. Murray, G. Weinstock (2002)
Involvement of PhoP-PhoS Homologs in Enterococcus faecalis VirulenceInfection and Immunity, 70
K. Walker, V. Miller (2004)
Regulation of the Ysa Type III Secretion System of Yersinia enterocolitica by YsaE/SycB and YsrS/YsrRJournal of Bacteriology, 186
T. Zahrt, V. Deretic (2001)
Mycobacterium tuberculosis signal transduction system required for persistent infectionsProceedings of the National Academy of Sciences of the United States of America, 98
G. Tejada, P. Cotter, U. Heininger, A. Camilli, B. Akerley, J. Mekalanos, Jeff Miller (1998)
Neither the Bvg− Phase nor thevrg6 Locus of Bordetella pertussis Is Required for Respiratory Infection in MiceInfection and Immunity, 66
J. Souza-Hart, W. Blackstock, V. Modugno, I. Holland, M. Kok (2003)
Two-Component Systems in Haemophilus influenzae: a Regulatory Role for ArcA in Serum ResistanceInfection and Immunity, 71
M. Fernández-Mora, J. Puente, E. Calva (2004)
OmpR and LeuO Positively Regulate the Salmonella enterica Serovar Typhi ompS2 Porin GeneJournal of Bacteriology, 186
Maria Bernardini, A. Fontaine, P. Sansonetti (1990)
The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneriJournal of Bacteriology, 172
I. Gryllos, J. Levin, M. Wessels (2003)
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+Proceedings of the National Academy of Sciences of the United States of America, 100
J. Shea, C. Beuzón, Colin Gleeson, R. Mundy, D. Holden (1999)
Influence of the Salmonella typhimuriumPathogenicity Island 2 Type III Secretion System on Bacterial Growth in the MouseInfection and Immunity, 67
N. Dasgupta, V. Kapur, Krishna Singh, T. Das, S. Sachdeva, K. Jyothisri, J. Tyagi (2000)
Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis.Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 80 3
P. Fields, E. Groisman, F. Heffron (1989)
A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.Science, 243 4894 Pt 1
T. Shimamura, S. Watanabe, S. Sasaki (1985)
Enhancement of enterotoxin production by carbon dioxide in Vibrio choleraeInfection and Immunity, 49
The relevance toward virulence of a variety of two-component signal transduction systems is reviewed for 16 pathogenic bacteria, together with the wide array of environmental signals or conditions that have been implicated in their regulation. A series of issues is raised, concerning the need to understand the environmental cues that determine their regulation in the infected host and in the environment outside the laboratory, which shall contribute toward the bridging of bacterial pathogenesis and microbial ecology.
Microbial Ecology – Springer Journals
Published: Jan 31, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.