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Receptor Protein-Tyrosine Kinases and their Signal Transduction Pathways

Receptor Protein-Tyrosine Kinases and their Signal Transduction Pathways Cells modulate their activities in response to signals from their surrounding environment. Single cell organisms respond mainly to nutrient cues, many of which are able to cross the cell membrane. In multicellular organisms, how­ ever, a much more constant milieu bathes the individual cells and reduces the need for cells to respond to nutritional signals. Instead, the need to coordinate the activities of one cell with those of its neighbors has resulted in the evolution of complex intercellular signaling pathways. Many of the activities of vertebrate cells are controlled by extracellular signaling molecules. The signals are often transduced across the cellular mem­ brane by transmembrane receptors. One type of receptor has intrinsic protein­ tyrosine kinase (PTK) activity and belongs to the receptor protein-tyrosine kinase (RPTK) family. RPTKs have been found in all multicellular eukaryotic organisms. These receptors are involved in the regulation of many cellular programs; the most notable are the control of cell growth and differentiation. Because of these properties, this class of molecules is also important in the genesis of many neoplasias. RPTKs are activated by polypeptide ligands commonly known as growth factors, but more properly called cytokines. Most known ligands for RPTKs are secreted, soluble http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cell and Developmental Biology Annual Reviews

Receptor Protein-Tyrosine Kinases and their Signal Transduction Pathways

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Publisher
Annual Reviews
Copyright
Copyright 1994 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
1081-0706
eISSN
1530-8995
DOI
10.1146/annurev.cb.10.110194.001343
pmid
7888178
Publisher site
See Article on Publisher Site

Abstract

Cells modulate their activities in response to signals from their surrounding environment. Single cell organisms respond mainly to nutrient cues, many of which are able to cross the cell membrane. In multicellular organisms, how­ ever, a much more constant milieu bathes the individual cells and reduces the need for cells to respond to nutritional signals. Instead, the need to coordinate the activities of one cell with those of its neighbors has resulted in the evolution of complex intercellular signaling pathways. Many of the activities of vertebrate cells are controlled by extracellular signaling molecules. The signals are often transduced across the cellular mem­ brane by transmembrane receptors. One type of receptor has intrinsic protein­ tyrosine kinase (PTK) activity and belongs to the receptor protein-tyrosine kinase (RPTK) family. RPTKs have been found in all multicellular eukaryotic organisms. These receptors are involved in the regulation of many cellular programs; the most notable are the control of cell growth and differentiation. Because of these properties, this class of molecules is also important in the genesis of many neoplasias. RPTKs are activated by polypeptide ligands commonly known as growth factors, but more properly called cytokines. Most known ligands for RPTKs are secreted, soluble

Journal

Annual Review of Cell and Developmental Biology – Annual Reviews

Published: Nov 1, 1994

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